BRCA2 |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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識別子 |
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記号 | BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes |
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外部ID | OMIM: 600185 MGI: 109337 HomoloGene: 41 GeneCards: BRCA2 |
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遺伝子の位置 (ヒト) |
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| 染色体 | 13番染色体 (ヒト)[1] |
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| バンド | データ無し | 開始点 | 32,315,086 bp[1] |
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終点 | 32,400,268 bp[1] |
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遺伝子の位置 (マウス) |
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| 染色体 | 5番染色体 (マウス)[2] |
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| バンド | データ無し | 開始点 | 150,446,095 bp[2] |
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終点 | 150,493,794 bp[2] |
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遺伝子オントロジー |
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分子機能 | • DNA結合 • H4 histone acetyltransferase activity • H3 histone acetyltransferase activity • protease binding • histone acetyltransferase activity • 血漿タンパク結合 • gamma-tubulin binding • single-stranded DNA binding • protein C-terminus binding • identical protein binding
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細胞の構成要素 | • 中心体 • BRCA2-MAGE-D1 complex • secretory granule • 核質 • 微小管形成中心 • 細胞核 • 細胞骨格 • lateral element • 細胞質 • 細胞質基質 • 高分子複合体
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生物学的プロセス | • chordate embryonic development • ヌクレオチド除去修復 • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • DNA recombination • regulation of cytokinesis • replication fork protection • centrosome duplication • male meiosis I • negative regulation of mammary gland epithelial cell proliferation • positive regulation of mitotic cell cycle • 染色体構成 • 女性生殖腺発生 • inner cell mass cell proliferation • positive regulation of transcription, DNA-templated • telomere maintenance via recombination • 脳発生 • oocyte maturation • histone H3 acetylation • 精子形成 • intrinsic apoptotic signaling pathway in response to DNA damage • establishment of protein localization to telomere • histone H4 acetylation • cellular response to DNA damage stimulus • 細胞周期 • 細胞増殖 • response to gamma radiation • response to UV-C • response to X-ray • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • mitotic recombination-dependent replication fork processing • double-strand break repair via homologous recombination • DNA修復 • double-strand break repair • mitotic cytokinesis • 造血 • response to nutrient • meiotic DNA repair synthesis involved in reciprocal meiotic recombination • 乳房発達 • homologous chromosome orientation involved in meiotic metaphase I plate congression • エストラジオールへの反応 • multicellular organism growth • DNA synthesis involved in double-strand break repair via homologous recombination • meiotic recombination checkpoint signaling
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (タンパク質) | | |
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場所 (UCSC) | Chr 13: 32.32 – 32.4 Mb | Chr 13: 150.45 – 150.49 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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