RB1 |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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PDBのIDコード一覧 |
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1AD6, 1GH6, 1GUX, 1H25, 1N4M, 1O9K, 1PJM, 2AZE, 2QDJ, 2R7G, 3N5U, 3POM, 4ELJ, 4ELL, 4CRI |
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識別子 |
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記号 | RB1, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1 |
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外部ID | OMIM: 614041 MGI: 97874 HomoloGene: 272 GeneCards: RB1 |
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遺伝子の位置 (ヒト) |
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| 染色体 | 13番染色体 (ヒト)[1] |
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| バンド | データ無し | 開始点 | 48,303,744 bp[1] |
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終点 | 48,599,436 bp[1] |
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遺伝子の位置 (マウス) |
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| 染色体 | 14番染色体 (マウス)[2] |
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| バンド | データ無し | 開始点 | 73,421,113 bp[2] |
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終点 | 73,563,262 bp[2] |
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遺伝子オントロジー |
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分子機能 | • DNA結合 • DNA-binding transcription factor activity • transcription coactivator activity • 転写因子結合 • phosphoprotein binding • キナーゼ結合 • 血漿タンパク結合 • androgen receptor binding • identical protein binding • 酵素結合 • ubiquitin protein ligase binding • importin-alpha family protein binding • disordered domain specific binding • cis-regulatory region sequence-specific DNA binding • DNA-binding transcription repressor activity, RNA polymerase II-specific
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細胞の構成要素 | • PML body • SWI/SNF complex • transcription regulator complex • 紡錘体 • P-TEFb • クロマチン • 細胞核 • 核質 • Rb-E2F complex
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生物学的プロセス | • negative regulation of cell population proliferation • negative regulation of mitotic cell cycle • neuron apoptotic process • androgen receptor signaling pathway • クロマチンリモデリング • negative regulation of smoothened signaling pathway • negative regulation of protein kinase activity • cell morphogenesis involved in neuron differentiation • mitotic cell cycle checkpoint signaling • regulation of transcription by RNA polymerase II • positive regulation of macrophage differentiation • 生体異物刺激に対する細胞応答 • negative regulation of cell cycle • negative regulation of DNA-binding transcription factor activity • transcription, DNA-templated • glial cell apoptotic process • regulation of cohesin loading • regulation of cell cycle • neuron maturation • 細胞分裂 • positive regulation of transcription, DNA-templated • negative regulation of G1/S transition of mitotic cell cycle • positive regulation of mitotic metaphase/anaphase transition • regulation of centromere complex assembly • enucleate erythrocyte differentiation • neuron differentiation • regulation of mitotic cell cycle • negative regulation of epithelial cell proliferation • skeletal muscle cell differentiation • sister chromatid biorientation • protein localization to chromosome, centromeric region • 細胞周期 • striated muscle cell differentiation • Ras protein signal transduction • myoblast differentiation • viral process • negative regulation of transcription, DNA-templated • neuron projection development • 消化管発生 • maintenance of mitotic sister chromatid cohesion • regulation of lipid kinase activity • positive regulation of transcription by RNA polymerase II • hepatocyte apoptotic process • アポトーシス • positive regulation of transcription regulatory region DNA binding • 遺伝子発現の負の調節 • regulation of cell growth • tissue homeostasis • regulation of transcription, DNA-templated • G1/S transition of mitotic cell cycle • negative regulation of transcription by RNA polymerase II • negative regulation of transcription involved in G1/S transition of mitotic cell cycle • chromatin organization • aortic valve morphogenesis • negative regulation of inflammatory response • positive regulation of extracellular matrix organization • positive regulation of collagen fibril organization • negative regulation of myofibroblast differentiation • 細胞分化 • negative regulation of cold-induced thermogenesis • negative regulation of protein serine/threonine kinase activity • negative regulation of tau-protein kinase activity • negative regulation of apoptotic signaling pathway
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (タンパク質) | | |
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場所 (UCSC) | Chr 13: 48.3 – 48.6 Mb | Chr 13: 73.42 – 73.56 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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