SH2B2

SH2B2 구조

SH2B 어댑터 단백질 2(SH2B Adapter Protein) 또는 SH2B2는 인간에서 유전자에 의해 암호화되는 단백질이다.[1][2]

기능

이 유전자에 의해 암호화된 단백질은 B 림프구로 발현되고 플렉스트린 상동성(Pleckstrin Homology) 및 src 상동성 2 도메인(SH2 Domain)을 포함한다. 버킷 림프종 세포주에서, 그것은 B 세포 수용체 자극에 반응하여 인산화 된 티로신이다. 자극 후 자극 및 Grb2와 독립적으로 Shc에 결합하기 때문에, 수용체로부터 Shc/Grb2로의 신호 전달에 역할을 하는 것으로 보인다.[2]

상호 작용

SH2B2는 TrkA[3] 및 Cbl 유전자와 상호 작용 하는 것으로 나타났다.[4][5]

각주

  1. ↑ “Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation”. 《Oncogene》 15 (1): 7–15. Aug 1997. doi:10.1038/sj.onc.1201163. PMID 9233773. 
  2. ↑ 가 나 “Entrez Gene: SH2B2 SH2B adaptor protein 2”. 
  3. ↑ “Identification and characterization of novel substrates of Trk receptors in developing neurons”. 《Neuron》 21 (5): 1017–29. Nov 1998. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458. 
  4. ↑ “APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl”. 《Leukemia》 13 (5): 760–7. May 1999. doi:10.1038/sj/leu/2401397. PMID 10374881. 
  5. ↑ “Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates”. 《EMBO J.》 27 (5): 804–16. Mar 2008. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061. 

외부 링크

  • “Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes”. 《Genome Res.》 8 (10): 1060–73. 1998. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793. 
  • “Identification and characterization of novel substrates of Trk receptors in developing neurons”. 《Neuron》 21 (5): 1017–29. 1999. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458. 
  • “APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis”. 《Oncogene》 18 (3): 759–67. 1999. doi:10.1038/sj.onc.1202326. PMID 9989826. 
  • “Identification of the APS protein as a novel insulin receptor substrate”. 《J. Biol. Chem.》 274 (16): 11186–93. 1999. doi:10.1074/jbc.274.16.11186. PMID 10196204. 
  • “APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl”. 《Leukemia》 13 (5): 760–7. 1999. doi:10.1038/sj/leu/2401397. PMID 10374881. 
  • “Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins”. 《Biochem. Biophys. Res. Commun.》 272 (1): 45–54. 2000. doi:10.1006/bbrc.2000.2736. PMID 10872802. 
  • “SH2-B family members differentially regulate JAK family tyrosine kinases”. 《J. Biol. Chem.》 277 (10): 8673–81. 2002. doi:10.1074/jbc.M109165200. PMID 11751854. 
  • “APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes”. 《Mol. Cell. Biol.》 22 (11): 3599–609. 2002. doi:10.1128/MCB.22.11.3599-3609.2002. PMC 133825. PMID 11997497. 
  • “Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity”. 《Oncogene》 21 (50): 7720–9. 2002. doi:10.1038/sj.onc.1205927. PMID 12400014. 
  • “Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling”. 《J. Biol. Chem.》 279 (20): 21526–32. 2004. doi:10.1074/jbc.M307740200. PMID 15031295. 
  • “Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex”. 《J. Biol. Chem.》 279 (37): 38881–8. 2004. doi:10.1074/jbc.M406101200. PMID 15231829. 
  • “Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins”. 《J. Biol. Chem.》 280 (19): 18943–9. 2005. doi:10.1074/jbc.M414157200. PMID 15737992. 
  • “APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation”. 《Biochem. Biophys. Res. Commun.》 330 (3): 1005–13. 2005. doi:10.1016/j.bbrc.2005.03.073. PMID 15809095. 
  • “Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588”. 《J. Biol. Chem.》 280 (45): 37827–32. 2006. doi:10.1074/jbc.M505959200. PMID 16141217. 
  • “Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling”. 《Endocrinology》 148 (4): 1615–21. 2007. doi:10.1210/en.2006-1010. PMC 4710543. PMID 17204555. 
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PDB 갤러리
  • 1q2h: Phenylalanine Zipper Mediates APS Dimerization
    1q2h: Phenylalanine Zipper Mediates APS Dimerization
  • 1rpy: CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
    1rpy: CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
  • 1rqq: Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
    1rqq: Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
  • 1v5m: Solution Structure of the Pleckstrin Homology Domain of Mouse APS
    1v5m: Solution Structure of the Pleckstrin Homology Domain of Mouse APS