DUSP22

Estruturas disponíveis

PDB

Pesquisa Human UniProt: PDBe RCSB

Lista de códigos id do PDB
1WRM, 4WOH

Identificadores

Nomes alternativos

DUSP22, Proteína fosfatase de dupla especificidade 22

IDs externos

OMIM: 616778 HomoloGene: 86039 GeneCards: DUSP22

Ontologia genética
Função molecular	• protein tyrosine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • protein tyrosine kinase binding
Componente celular	• citoplasma • núcleo celular • citosol • membrana plasmática • filamentous actin • leading edge of lamellipodium
Processo biológico	• multicellular organism development • negative regulation of T cell mediated immunity • GO:0016576 protein dephosphorylation • peptidyl-tyrosine dephosphorylation • Proliferação celular • negative regulation of T cell activation • GO:1901227 negative regulation of transcription by RNA polymerase II • transforming growth factor beta receptor signaling pathway • regulation of cell population proliferation • positive regulation of JNK cascade • negative regulation of T cell receptor signaling pathway • GO:0098501, GO:0098502, GO:0006286 Desfosforilação • GO:0097285 apoptose • negative regulation of cell migration • negative regulation of focal adhesion assembly • cellular response to epidermal growth factor stimulus • negative regulation of non-membrane spanning protein tyrosine kinase activity
Sources:Amigo / QuickGO

Padrão de expressão RNA

Mais dados de referência de expressão

Ortólogos

Espécie

Humano

Rato

Entrez


56940


n/a

Ensembl


ENSG00000112679


n/a

UniProt


Q9NRW4


n/a

RefSeq (mRNA)


NM_001286555 NM_020185


n/a

RefSeq (proteína)


NP_001273484 NP_064570


n/a

Localização (UCSC)

n/a

Pesquisa PubMed

^[1]

n/a

Wikidata

Ver/Editar Humano

A Proteína fosfatase de dupla especificidade 22 é uma proteína que em humanos é codificada pelo gene DUSP22.^[2]^[3]^[4]

Interações

Demonstrou-se que o DUSP22 interage com MAPK1^[5] e MAPK8.^[5]

Referências

↑ «Human PubMed Reference:»
↑ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (setembro de 1997). «Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)». Genomics. 42 (3): 524–7. PMID 9205128. doi:10.1006/geno.1997.4756
↑ Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (novembro de 2001). «Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1». Proc Natl Acad Sci U S A. 98 (24): 13613–8. Bibcode:2001PNAS...9813613S. PMC 61089. PMID 11717427. doi:10.1073/pnas.231499098
↑ «Entrez Gene: DUSP22 dual specificity phosphatase 22»
↑ ^a ^b Aoyama, K; Nagata M; Oshima K; Matsuda T; Aoki N (julho de 2001). «Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain». J. Biol. Chem. 276 (29): 27575–83. ISSN 0021-9258. PMC 3757226. PMID 11346645. doi:10.1074/jbc.M100408200

Leitura adicional

Aoyama K, Nagata M, Oshima K, et al. (2001). «Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain.». J. Biol. Chem. 276 (29): 27575–83. PMC 3757226. PMID 11346645. doi:10.1074/jbc.M100408200
Alonso A, Merlo JJ, Na S, et al. (2002). «Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR).». J. Biol. Chem. 277 (7): 5524–8. PMID 11733513. doi:10.1074/jbc.M107653200
Chen AJ, Zhou G, Juan T, et al. (2002). «The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.». J. Biol. Chem. 277 (39): 36592–601. PMID 12138158. doi:10.1074/jbc.M200453200
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6.». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
Alonso A, Narisawa S, Bogetz J, et al. (2004). «VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.». J. Biol. Chem. 279 (31): 32586–91. PMID 15138252. doi:10.1074/jbc.M403442200
Fortna A, Kim Y, MacLaren E, et al. (2004). «Lineage-specific gene duplication and loss in human and great ape evolution.». PLoS Biol. 2 (7): E207. PMC 449870. PMID 15252450. doi:10.1371/journal.pbio.0020207
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Yokota T, Nara Y, Kashima A, et al. (2007). «Crystal structure of human dual specificity phosphatase, JNK stimulatory phosphatase-1, at 1.5 A resolution.». Proteins. 66 (2): 272–8. PMID 17068812. doi:10.1002/prot.21152
Sekine Y, Ikeda O, Hayakawa Y, et al. (2007). «DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.». Oncogene. 26 (41): 6038–49. PMID 17384676. doi:10.1038/sj.onc.1210426
Mélard P, Idrissi Y, Andrique L, et al. (2016). «Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.». Oncotarget. 7 (42): 68734–48. PMC 5356586. PMID 27626696. doi:10.18632/oncotarget.11930