FUT9

Identificadores

Nomes alternativos

FUT9

IDs externos

OMIM: 606865 HomoloGene: 4800 GeneCards: FUT9

Ontologia genética
Função molecular	• glycosyltransferase activity • alpha-(1->3)-fucosyltransferase activity • fucosyltransferase activity • transferase activity
Componente celular	• integral component of membrane • complexo de Golgi • Golgi cisterna membrane • membrane • Golgi membrane
Processo biológico	• L-fucose catabolic process • fucosylation • nervous system development • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • carbohydrate metabolic process
Sources:Amigo / QuickGO

Padrão de expressão RNA

Mais dados de referência de expressão

Ortólogos

Espécie

Humano

Rato

Entrez


10690


n/a

Ensembl


ENSG00000172461


n/a

UniProt


Q9Y231


n/a

RefSeq (mRNA)


NM_006581


n/a

RefSeq (proteína)


NP_006572


n/a

Localização (UCSC)

n/a

Pesquisa PubMed

^[1]

n/a

Wikidata

Ver/Editar Humano

Alfa (1,3)-fosiltransferase é uma proteína que em humanos é codificada pelo gene FUT9.^[2]^[3]^[4]

O FUT9 é uma das várias alfa-3-fucosiltransferases que podem catalisar o último passo na biossíntese do antígeno de Lewis, a adição de uma fucose aos polissacarídeos precursores. O FUT9 sintetiza o oligossacarídeo LeX (CD15), expresso em brotos de órgãos progredindo no mesênquima durante a embriogênese humana.^[4]

Referências

↑ «Human PubMed Reference:»
↑ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (julho de 1999). «Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX». FEBS Lett. 452 (3): 237–42. PMID 10386598. doi:10.1016/S0014-5793(99)00640-7
↑ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (janeiro de 2000). «Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization». Cytogenet Cell Genet. 86 (3–4): 329–30. PMID 10575236. doi:10.1159/000015329
↑ ^a ^b «Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)»

Leitura adicional

Bonaldo MF, Lennon G, Soares MB (1997). «Normalization and subtraction: two approaches to facilitate gene discovery». Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791
Nishihara S, Iwasaki H, Kaneko M, et al. (2000). «Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue». FEBS Lett. 462 (3): 289–94. PMID 10622713. doi:10.1016/S0014-5793(99)01549-5
Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). «FUT4 and FUT9 genes are expressed early in human embryogenesis». Glycobiology. 10 (8): 789–802. PMID 10929005. doi:10.1093/glycob/10.8.789
Nakayama F, Nishihara S, Iwasaki H, et al. (2001). «CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV». J. Biol. Chem. 276 (19): 16100–6. PMID 11278338. doi:10.1074/jbc.M007272200
Roos C, Kolmer M, Mattila P, Renkonen R (2002). «Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism». J. Biol. Chem. 277 (5): 3168–75. PMID 11698403. doi:10.1074/jbc.M107927200
Toivonen S, Nishihara S, Narimatsu H, et al. (2003). «Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile». Glycobiology. 12 (6): 361–8. PMID 12107078. doi:10.1093/glycob/12.6.361
Li H, Kong Y, Yan B (2003). «[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]». Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (6): 775–9. PMID 12417923
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899
Nishihara S, Iwasaki H, Nakajima K, et al. (2004). «Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain». Glycobiology. 13 (6): 445–55. PMID 12626397. doi:10.1093/glycob/cwg048
Mungall AJ, Palmer SA, Sims SK, et al. (2003). «The DNA sequence and analysis of human chromosome 6». Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)». Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504
Bogoevska V, Horst A, Klampe B, et al. (2006). «CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues». Glycobiology. 16 (3): 197–209. PMID 16282604. doi:10.1093/glycob/cwj057