1-Amino-1,3-dikarboksiciklopentan
1-Amino-1,3-dikarboksiciklopentan | |||
---|---|---|---|
![]() | |||
Naziv po klasifikaciji | 1-Aminociklopentan-1,3-dikarboksilna kiselina[1] | ||
Identifikacija | |||
Abrevijacija | ACPD | ||
CAS registarski broj | 39026-63-6 ![]() | ||
PubChem[2][3] | 1310, 44381972 (1S), 231345 (1R,3R), 73537 (1R,3S), 104766 (1S,3R), 6604704 (1S,3S) | ||
ChemSpider[4] | 1270 ![]() ![]() ![]() ![]() ![]() | ||
MeSH | 1-amino-1,3-dicarboxycyclopentane | ||
ChEMBL[5] | CHEMBL168278 ![]() | ||
RTECS registarski broj toksičnosti | GY4060000 (1S,3R) | ||
Jmol-3D slike | Slika 1 | ||
| |||
| |||
Svojstva | |||
Molekulska formula | C7H11NO4 | ||
Molarna masa | 173.17 g mol−1 | ||
Agregatno stanje | Beli kristali | ||
Rastvorljivost u vodi | 20 g dm-3 | ||
Rastvorljivost u etanol | 240 mg dm-3 | ||
log P | -0,709 | ||
pKa | 2,112 | ||
Baznost (pKb) | 11,885 | ||
Izoelektrična tačka | 2,84 | ||
Opasnost | |||
EU-klasifikacija | ![]() | ||
R-oznake | R20/21/22, R36/37/38 | ||
S-oznake | S26, S36/37 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).[6] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.[7] ACPD može da indukuje konvulzije kod neonatalnih pacova.[8]
Reference
- ↑ „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005.. Identification and Related Records. Pristupljeno 15. 10. 2011.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Schoepp DD, True RA (September 1992). „1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes”. Neurosci. Lett. 145 (1): 100–4. DOI:10.1016/0304-3940(92)90213-Q. PMID 1461560.
- ↑ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (July 1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol. 38 (1): 1–6. PMID 2164627. [mrtav link]
- ↑ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (October 1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci. 13 (10): 4445–55. PMID 8410197.
- p
- r
- u
Agonisti: Neselektivni: ACPD • DHPG • Kuiskualinska kiselina; mGlu1-selektivni: Ro01-6128 • Ro67-4853 • Ro67-7476 • VU-71; mGlu5-selektivni: ADX-47273 • CDPPB • CHPG • DFB • VU-1545 Antagonisti: Neselektivni: MCPG • NPS-2390; mGlu1-selektivni: BAY 36-7620 • CPCCOEt • LY-367,385 • LY-456,236; mGlu5-selektivni: DMeOB • Fenobam • LY-344,545 • MPEP • MTEP • SIB-1757 • SIB-1893 | |
Agonisti: Neselektivni: CBiPES • DCG-IV • Eglumegad • LY-379,268 • LY-404,039 • LY-487,379 • MGS-0028; mGlu2-selektivni: BINA • LY-566,332 Antagonisti: Neselektivni: APICA • EGLU • HYDIA • LY-307,452 • LY-341,495 • MCPG • MGS-0039; mGlu2-selektivni: PCCG-4; mGlu3-selektivni: CECXG; Negativni alosterni modulatori: RO4491533 | |
transporta
DHKA • PDC • WAY-213,613 | |