APICA (lek)
(IUPAC) ime | |||
---|---|---|---|
1-Amino-5-fosfonoindan-1-karboksilna kiselina | |||
Klinički podaci | |||
Identifikatori | |||
ATC kod | nije dodeljen | ||
ChemSpider[1] | 3881975 | ||
ChEMBL[2] | CHEMBL277961 Y | ||
Hemijski podaci | |||
Formula | C10H12NO5P | ||
Mol. masa | 257,179 g/mol | ||
SMILES | eMolekuli & PubHem | ||
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Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
1-Amino-5-fosfonoindan-1-karboksilna kiselina (APICA) je lek koji se koristi u neurološkim istraživanjima. on je selektivni antagonist za grupu II metabotropnih glutamatnih receptora (mGluR2/3), i bio je koristan u istraživanju te receptorske potfamilije.[3][4][5][6][7]
Reference
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Ma D, Tian H, Sun H, Kozikowski AP, Pshenichkin S, Wroblewski JT. Synthesis and biological activity of cyclic analogues of MPPG and MCPG as metabotropic glutamate receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 1997 May 6;7(9):1195-1198. doi:10.1016/S0960-894X(97)00177-7
- ↑ Ma D, Tian H, Zou G. Asymmetric Strecker-Type Reaction of alpha-Aryl Ketones. Synthesis of (S)-alphaM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the Antagonists of Metabotropic Glutamate Receptors. Journal of Organic Chemistry. 1999 Jan 8;64(1):120-125. PMID 11674092
- ↑ Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens. Journal of Pharmacology and Experimental Therapeutics. 2002 Jan;300(1):162-71. DOI:10.1124/jpet.300.1.162 PMID 11752112
- ↑ Baker DA, Xi ZX, Shen H, Swanson CJ, Kalivas PW. The origin and neuronal function of in vivo nonsynaptic glutamate. Journal of Neuroscience. 2002 Oct 15;22(20):9134-41. PMID 12388621
- ↑ Zhou F, Yao HH, Wu JY, Yang YJ, Ding JH, Zhang J, Hu G. Activation of Group II/III metabotropic glutamate receptors attenuates LPS-induced astroglial neurotoxicity via promoting glutamate uptake. Journal of Neuroscience Research. 2006 Aug 1;84(2):268-77. PMID 16752416
Spoljašnje veze
Portal Medicina | |
Portal Hemija |
- p
- r
- u
Glutamatergični ligandi
Agonisti: Neselektivni: ACPD • DHPG • Kuiskualinska kiselina; mGlu1-selektivni: Ro01-6128 • Ro67-4853 • Ro67-7476 • VU-71; mGlu5-selektivni: ADX-47273 • CDPPB • CHPG • DFB • VU-1545 Antagonisti: Neselektivni: MCPG • NPS-2390; mGlu1-selektivni: BAY 36-7620 • CPCCOEt • LY-367,385 • LY-456,236; mGlu5-selektivni: DMeOB • Fenobam • LY-344,545 • MPEP • MTEP • SIB-1757 • SIB-1893 | |
Agonisti: Neselektivni: CBiPES • DCG-IV • Eglumegad • LY-379,268 • LY-404,039 • LY-487,379 • MGS-0028; mGlu2-selektivni: BINA • LY-566,332 Antagonisti: Neselektivni: APICA • EGLU • HYDIA • LY-307,452 • LY-341,495 • MCPG • MGS-0039; mGlu2-selektivni: PCCG-4; mGlu3-selektivni: CECXG; Negativni alosterni modulatori: RO4491533 | |
transporta
DHKA • PDC • WAY-213,613 | |