Diacilglicerol O-aciltransferaza
| Diacilglicerol O-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.20 | ||||||||
| CAS broj | 9029-98-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diacilglicerol O-aciltransferaza (EC 2.3.1.20, digliceridna aciltransferaza, 1,2-diacilglicerolna aciltransferaza, diacilglicerolna aciltransferaza, digliceridna O-aciltransferaza, palmitoil-KoA-sn-1,2-diacilglicerol aciltransferaza, acil-KoA:1,2-diacilglicerol O-aciltransferaza) je enzim sa sistematskim imenom acil-KoA:1,2-diacil-sn-glicerol O-aciltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA + 1,2-diacil-sn-glicerol KoA + triacilglicerol
Palmitoil-KoA i drugi dugolančani acil-KoAs mogu da deluju kao donori.
Reference
- ↑ Coleman, R. and Bell, R.M. (1976). „Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols”. J. Biol. Chem. 251: 4537-4543. PMID 947894.
- ↑ Grigor, M.R. and Bell, R.M. (1982). „Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis”. Biochim. Biophys. Acta 712: 464-472. PMID 6289909.
- ↑ Kawasaki, T. and Snyder, F. (1988). „Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells”. J. Biol. Chem. 263: 2593-2596. PMID 3422635.
- ↑ Weiss, S.B., Kennedy, E.P. and Kiyasu, J.Y. (1960). „The enzymatic synthesis of triglycerides”. J. Biol. Chem. 235: 40-44. PMID 13843753.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Diacylglycerol+O-acyltransferase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
