EPHA7

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EPH receptor A7

Prikaz baziran na PDB 2REI.
Dostupne strukture
2REI, 3DKO, 3H8M, 3NRU
Identifikatori
SimboliEPHA7; EHK-3; EHK3; EK11; HEK11
Vanjski IDOMIM: 602190 MGI: 95276 HomoloGene: 20935 GeneCards: EPHA7 Gene
EC broj2.7.10.1
Ontologija gena
Molekulska funkcija • aktivnost proteinske tirozinske kinaze
• aktivnost GPI-vezanog efrinskog receptora
• proteinsko vezivanje
Ćelijska komponenta • integralna komponenta ćelijske membrane
• dendrit
• neuromuskularni spoj
Biološki proces • razviće mozga
• fosforilacija
• peptidil-tirozinska fosforilacija
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez204513841
EnsemblENSG00000135333ENSMUSG00000028289
UniProtQ15375Q61772
Ref. Sekv. (iRNK)NM_001288629NM_001122889
Ref. Sekv. (protein)NP_001275558NP_001116361
Lokacija (UCSC)Chr 6:
93.95 - 94.13 Mb		Chr 4:
28.81 - 28.97 Mb
PubMed pretraga[1][2]

Receptor 7 efrinskog tipa A je protein koji je kod ljudi kodiran EPHA7 genom.[1][2]

Ovaj gen je pripadnik grupe efrinskih receptora iz familije proteinskih turozinskih kinaza. EPH i EPH-srodni receptori uzimaju učešća u posredovanju događaja razvića, posebno u nervnom sistemu. Receptori EPH podfamilije tipično imaju jedan kinazni domen, ekstracelularni region koji sadrži domen bogat cisteinom i dva ponavljanja fibronektinskog tipa III. Efrinski receptori se dele u dve grupe na bazi sličnosti sekvenci njihovih ekstracelularnih domena i njihovih afiniteta vezivanja liganda efrina A i efrina B.[2]

Reference

  1. ↑ Ephnomenclaturecommittee (Sep 1997). „Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee”. Cell 90 (3): 403–4. DOI:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  2. ↑ 2,0 2,1 „Entrez Gene: EPHA7 EPH receptor A7”. 

Literatura

  • Flanagan JG, Vanderhaeghen P (1998). „The ephrins and Eph receptors in neural development”. Annu. Rev. Neurosci. 21: 309–45. DOI:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). „The Eph family receptors and ligands”. Pharmacol. Ther. 77 (3): 151–81. DOI:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
  • Holder N, Klein R (1999). „Eph receptors and ephrins: effectors of morphogenesis”. Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). „Eph receptors and ephrins: regulators of guidance and assembly”. Int. Rev. Cytol.. International Review of Cytology 196: 177–244. DOI:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). „Roles of Eph receptors and ephrins in segmental patterning”. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. DOI:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
  • Wilkinson DG (2001). „Multiple roles of EPH receptors and ephrins in neural development”. Nat. Rev. Neurosci. 2 (3): 155–64. DOI:10.1038/35058515. PMID 11256076. 
  • Fox GM, Holst PL, Chute HT, et al. (1995). „cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases”. Oncogene 10 (5): 897–905. PMID 7898931. 
  • Gale NW, Holland SJ, Valenzuela DM, et al. (1996). „Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis”. Neuron 17 (1): 9–19. DOI:10.1016/S0896-6273(00)80276-7. PMID 8755474. 
  • Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791–806. DOI:10.1101/gr.6.9.791. PMID 8889548. 
  • Ciossek T, Ullrich A (1997). „Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1”. Oncogene 14 (1): 35–43. DOI:10.1038/sj.onc.1200800. PMID 9010230. 
  • Hock B, Böhme B, Karn T, et al. (1998). „PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. DOI:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552. 
  • Bianchi LM, Liu H (1999). „Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear”. Anat. Rec. 254 (1): 127–34. DOI:10.1002/(SICI)1097-0185(19990101)254:1<127::AID-AR16>3.0.CO;2-Q. PMID 9892426. 
  • Janis LS, Cassidy RM, Kromer LF (1999). „Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum”. J. Neurosci. 19 (12): 4962–71. PMID 10366629. 
  • Stubbs J, Palmer A, Vidovic M, Marotte LR (2000). „Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection”. Eur. J. Neurosci. 12 (10): 3626–36. DOI:10.1046/j.1460-9568.2000.00251.x. PMID 11029633. 
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EPH receptorska familija
EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX
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B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6