Glicerol-3-fosfat dehidrogenaza (NAD+)

Glicerol-3-fosfat dehidrogenaza (NAD+)
Identifikatori
EC broj 1.1.1.8
CAS broj 9075-65-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
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PMC articles
PubMed articles
NCBI Protein search

Glicerol-3-fosfat dehidrogenaza (NAD+) (EC 1.1.1.8, glicerol-3-fosfatna dehidrogenaza (NAD+), alfa-glicerol fosfat dehidrogenaza (NAD+), alfa-glicerofosfat dehidrogenaza (NAD+), glicerol 1-fosfat dehidrogenaza, glicerol fosfat dehidrogenaza (NAD+), glicerofosfat dehidrogenaza (NAD+), hidroglicerofosfat dehidrogenaza, L-alfa-glicerol fosfat dehidrogenaza, L-alfa-glicerofosfat dehidrogenaza, L-glicerol fosfat dehidrogenaza, L-glicerofosfat dehidrogenaza, NAD+-alfa-glicerofosfat dehidrogenaza, NAD+-zavisna glicerol fosfat dehidrogenaza, NAD+-zavisna glicerol-3-fosfat dehidrogenaza, NAD+-L-glicerol-3-fosfat dehidrogenaza, NAD+-vezani glicerol 3-fosfat dehidrogenaza, NADH-dihidroksiaceton fosfat reduktaza, L-glicerol-3-fosfat dehidrogenaza) je enzim sa sistematskim imenom sn-glicerol-3-fosfat:NAD+ 2-oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

sn-glicerol 3-fosfat + NAD+ ⇌ {\displaystyle \rightleftharpoons } gliceron fosfat + NADH + H+

Ovaj enzim takođe deluje na propan-1,2-diol fosfat and gliceron sulfat (mada sa znatno manjim afinitetom).

Reference

  1. ↑ Baranowski, T. (1963). „α-Glycerophosphate dehydrogenase”. u: Boyer, P.D., Lardy, H. and Myrbäck, K.. The Enzymes. 7 (2nd izd.). New York: Academic Press. str. 85-96. 
  2. ↑ Brosemer, R.W. and Kuhn, R.W. (1969). „Comparative structural properties of honeybee and rabbit α-glycerophosphate dehydrogenases”. Biochemistry 8: 2095-2105. PMID 4307630. 
  3. ↑ O'Brien, S.J. and MacIntyre, R.J. (1972). „The α-glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects”. Biochem. Genet. 7: 141-161. PMID 4340553. 
  4. ↑ Warkentin, K.L. and Fondy, T.P. (1973). „Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme”. Eur. J. Biochem. 36: 97-109. PMID 4200180. 
  5. ↑ Albertyn, J., van Tonder, A. and Prior, B.A. (1992). „Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae”. FEBS Lett. 308: 130-132. PMID 1499720. 
  6. ↑ Koekemoer, T.C., Litthauer, D. and Oelofsen, W. (1995). „Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase”. Int. J. Biochem. Cell Biol. 27: 625-632. PMID 7671141. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Spoljašnje veze

  • MeSH Glycerol-3-phosphate+dehydrogenase+(NAD+)
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TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6