Karbamoil-fosfatna sintaza (amonijak)
Karbamoil-fosfatna sintaza (amonijak) | |||||||||
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Identifikatori | |||||||||
EC broj | 6.3.4.16 | ||||||||
CAS broj | 9026-23-7 | ||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Karbamoil-fosfatna sintaza (amonijak) (EC 6.3.4.16, ugljen-dioksid—amonijak ligaza, karbamoilfosfatna sintaza, karbamilfosfatna sintetaza, karbamoilfosfatna sintaza (amonijak), karbamoilfosfatna sintetaza, karbamilfosfatna sintetaza I) je enzim sa sistematskim imenom ugljen-dioksid:amonijak ligaza (formira ADP, karbamatna fosforilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 ATP + NH3 + CO2 + H2O 2 ADP + fosfat + karbamoil fosfat
Reference
- ↑ Fahien, L.A. and Cohen, P.P. (1964). „A kinetic study of carbamyl phosphate synthetase”. J. Biol. Chem. 239: 1925-1934. PMID 14213379.
- ↑ Jones, M.E. and Spector, L. (1960). „The pathway of carbonate in the biosynthesis of carbamyl phosphate”. J. Biol. Chem. 235: 2897-2901. PMID 13790558.
- ↑ Marshall, M., Metzenberg, R.L. and Cohen, P.P. (1958). „Purification of carbamyl phosphate synthetase from frog liver”. J. Biol. Chem. 233: 102-105. PMID 13563449.
- ↑ Marshall, M., Metzenberg, R.L. and Cohen, P.P. (1961). „Physical and kinetic properties of carbamyl phosphate synthetase from frog liver”. J. Biol. Chem. 236: 2229-2237.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Carbamoyl-phosphate+synthase+(ammonia)
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6