KoB-KoM heterodisulfid reduktaza
| KoB-KoM heterodisulfid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.98.1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
KoB-KoM heterodisulfid reduktaza (EC 1.8.98.1, heterodisulfidna reduktaza, rastvorna heterodisulfidna reduktaza) je enzim sa sistematskim imenom koenzim B:koenzim M:metanofenazin oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- koenzim B + koenzim M + metanofenazin N7-[(2-sulfoetil)ditio]heptanoilO3-fosfo-L-treonin + dihidrometanofenazin
Ovaj enzim je prisutan kod metanogenih arheja, posebno kod metanosarcina vrsta. On regeneriše koenzim M i koenzim B nakon dejstva enzima EC 2.8.4.1, koenzim-B sulfoetiltiotransferaze.
Reference
- ↑ Hedderich, R., Berkessel, A. and Thauer, R.K. (1990). „Purification and properties of heterodisulfide reductase from Methanobacterium thermoautotrophicum (strain Marburg)”. Eur. J. Biochem. 193: 255-261. PMID 2121478.
- ↑ Abken, H.J., Tietze, M., Brodersen, J., Bäumer, S., Beifuss, U. and Deppenmeier, U. (1998). „Isolation and characterization of methanophenazine and function of phenazines in membrane-bound electron transport of Methanosarcina mazei gol”. J. Bacteriol. 180: 2027-2032. PMID 9555882.
- ↑ Simianu, M., Murakami, E., Brewer, J.M. and Ragsdale, S.W. (1998). „Purification and properties of the heme- and iron-sulfur-containing heterodisulfide reductase from Methanosarcina thermophila”. Biochemistry 37: 10027-10039. PMID 9665708.
- ↑ Murakami, E., Deppenmeier, U. and Ragsdale, S.W. (2001). „Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila”. J. Biol. Chem. 276: 2432-2439. PMID 11034998.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH CoB—CoM+heterodisulfide+reductase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
