Prolin dehidrogenaza
| Prolin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Prolin dehidrogenaza tetramer, Bradyrhizobium diazoefficiens | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.5.99.8 | ||||||||
| CAS broj | 9050-70-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Prolin dehidrogenaza (EC 1.5.99.8, L-prolinska dehidrogenaza, L-prolin:(akceptor) oksidoreduktaza) je enzim sa sistematskim imenom L-prolin:akceptor oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-prolin + akceptor (S)-1-pirolidin-5-karboksilat + redukovani akceptor
Ovaj enzim je flavoprotein (FAD). U mnogim organizmima, od bakterija do sisara, prolin se oksiduje do glutamata u dvostepenom procesu koji obuhvata ovaj enzim i EC 1.5.1.12, 1-pirolidin-5-karboksilat dehidrogenazu.
Reference
- ↑ Scarpulla, R.C. and Sofer, R.L. (1978). „Membrane-bound proline dehydrogenase from Escherichia coli. Solubilization, purification, and characterization”. J. Biol. Chem. 253: 5997-6001. PMID 355248.
- ↑ Forlani, G., Scainelli, D. and Nielsen, E. (1997). „Δ1-Pyrroline-5-carboxylate dehydrogenase from cultured cells of potato (purification and properties)”. Plant Physiol. 113: 1413-1418. PMID 12223682.
- ↑ Brown, E.D. and Wood, J.M. (1992). „Redesigned purification yields a fully functional PutA protein dimer from Escherichia coli”. J. Biol. Chem. 267: 13086-13092. PMID 1618807.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Proline+dehydrogenase
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
