Remikiren

(IUPAC) ime

(2S)-2-[(2R)-2-benzil-3-(2-metilpropan-2-sulfonil)propanamido]-N-[(2R,3S,4R)-1-cikloheksil-4-ciklopropil-3,4-dihidroksibutan-2-il]-3-(1H-imidazol-4-il)propanamid

Klinički podaci

Identifikatori

CAS broj

126222-34-2

ATC kod

C09XA01

PubChem^[1]^[2]

6324659

DrugBank

DB00212

ChemSpider^[3]

4884377

UNII

LC7FBL96A4^Y

KEGG^[4]

D09038^Y

ChEMBL^[5]

CHEMBL31601^Y

Hemijski podaci

Formula

C₃₃H₅₀N₄O₆S

Mol. masa

630,839 g/mol

SMILES

eMolekuli & PubHem

InChI
InChI=1S/C33H50N4O6S/c1-33(2,3)44(42,43)20-25(16-22-10-6-4-7-11-22)31(40)37-28(18-26-19-34-21-35-26)32(41)36-27(17-23-12-8-5-9-13-23)30(39)29(38)24-14-15-24/h4,6-7,10-11,19,21,23-25,27-30,38-39H,5,8-9,12-18,20H2,1-3H3,(H,34,35)(H,36,41)(H,37,40)/t25-,27+,28+,29+,30-/m1/s1^Y Key: UXIGZRQVLGFTOU-VQXQMPIVSA-N^Y

Farmakoinformacioni podaci

Trudnoća

Pravni status

Investigacioni

Remikiren je reninski inhibitor koji je u razvoju za tretman hipertenzije (visokog krvnog pritiska). Ovaj lek je razvilo preduzeće Hofman la Roš 1996. godine.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Richter WF, Whitby BR, Chou RC (1996). „Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals”. Xenobiotica 26 (3): 243–54. DOI:10.3109/00498259609046705. PMID 8730917.