Teduglutid
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Klinički podaci | |
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Prodajno ime | Gattex, Revestive |
Drugs.com | Monografija |
Način primene | Subkutano |
Farmakokinetički podaci | |
Poluvreme eliminacije | 2 h |
Identifikatori | |
CAS broj | 197922-42-2 ![]() |
ATC kod | A16AX08 (WHO) |
PubChem | CID 16139605 |
DrugBank | DB08900 ![]() |
KEGG | C16049 ![]() |
ChEBI | CHEBI:72305 ![]() |
Hemijski podaci | |
Formula | C164H252N44O55S |
Molarna masa | 3752.082 |
SMILES
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InChI
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Teduglutid (Gattex, Revestive) je 36 aminokiselina dug polipeptid i analog glukagonu sličanog peptida-2, koji se koristi za lečenje sindroma kratkog creva. Lek deluje putem podsticanja rasta sluzokože, i verovatno ponovnog uspostavljanja gastričnog pražnjenja i sekrecije.[1][2][3][4][5][6]
Reference
- ^ Jeppesen PB (2012). „Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome”. Therap Adv Gastroenterol. 5 (3): 159—71. PMC 3342570
. PMID 22570676. doi:10.1177/1756283X11436318.
- ^ Burness CB, McCormack PL: Teduglutide: A Review of its Use in the Treatment of Patients with Short Bowel Syndrome. Drugs. 2013 Jun 1. PMID 23729002
- ^ Semrad CE: The Long Road to a New Short-Bowel Therapy: Teduglutide for Clinical Use. Clin Gastroenterol Hepatol. 2013 Apr 13. pii: S1542-3565(13)00471-0. doi: 10.1016/j.cgh.2013.03.030. PMID 23591284
- ^ Jeppesen PB: Teduglutide, a novel glucagon-like peptide 2 analog, in the treatment of patients with short bowel syndrome. Therap Adv Gastroenterol. 2012 May;5(3):159-71. doi: 10.1177/1756283X11436318. PMID 22570676
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. уреди
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889
. PMID 18048412. doi:10.1093/nar/gkm958. уреди
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Teduglutide
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