Timin-DNK glikozilaza
| Timin-DNK glikozilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.2.2.29 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Timin-DNK glikozilaza (EC 3.2.2.29, za neusklađenost specifična timin-DNK glikozilaza, za neusklađenost specifična timin-DNK N-glikozilaza, hTDG, hsTDG, TDG, timinska DNK glikozilaza, G/T glikozilaza, uracil/timin DNK glikozilaza, T:G za neusklađenost specifična timidin-DNK glikozilaza, G:T za neusklađenost specifična timinska DNK-glikozilaza) je enzim sa sistematskim imenom timin-DNK dezoksiribohidrolaza (otpuštanje timina).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa timin
Zimin-DNK glikozilaza je deo mehanizma za popravku DNK.
Reference
- ^ Waters, T.R. & Swann, P.F. (2000). „Thymine-DNA glycosylase and G to A transition mutations at CpG sites”. Mutat. Res. 462: 137—147. PMID 10767625.
- ^ Neddermann, P. & Jiricny, J. (1993). „The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells”. J. Biol. Chem. 268: 21218—21224. PMID 8407958.
- ^ Waters, T.R. & Swann, P.F. (1998). „Kinetics of the action of thymine DNA glycosylase”. J. Biol. Chem. 273: 20007—20014. PMID 9685338.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
- Thymine-DNA+glycosylase на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
- EC1 Oksidoreduktaze /spisak
- EC2 Transferaze /spisak
- EC3 Hidrolaze /spisak
- EC4 Lijaze /spisak
- EC5 Izomeraze /spisak
- EC6 Ligaze /spisak
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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