EP300 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/5/58/Protein_EP300_PDB_1f81.png/250px-Protein_EP300_PDB_1f81.png) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3 | | |
Ідентифікатори |
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Символи | EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2 |
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Зовнішні ІД | OMIM: 602700 MGI: 1276116 HomoloGene: 1094 GeneCards: EP300 |
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Реагує на сполуку |
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Куркумін, Ґаллат епіґаллокатехіну, plumbagin[1] |
Онтологія гена |
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Молекулярна функція | • protein C-terminus binding • transcription factor binding • GO:0001104 transcription coregulator activity • зв'язування з іоном металу • acyltransferase activity • transferase activity • beta-catenin binding • pre-mRNA intronic binding • zinc ion binding • chromatin binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • acetyltransferase activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • p53 binding • androgen receptor binding • chromatin DNA binding • histone acetyltransferase activity • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor • peptide N-acetyltransferase activity • peptide-lysine-N-acetyltransferase activity • protein propionyltransferase activity • STAT family protein binding • peptide butyryltransferase activity • histone crotonyltransferase activity • histone butyryltransferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding |
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Клітинна компонента | • клітинне ядро • histone acetyltransferase complex • transcription regulator complex • нуклеоплазма • цитоплазма • гіалоплазма • хромосома |
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Біологічний процес | • somitogenesis • ритмічний процес • transcription by RNA polymerase II • histone H2B acetylation • animal organ morphogenesis • клітинний цикл • B cell differentiation • GO:0097285 апоптоз • GO:0009373 regulation of transcription, DNA-templated • lung development • N-terminal peptidyl-lysine acetylation • Тромбоцитопоез • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • regulation of transcription from RNA polymerase II promoter in response to hypoxia • GO:0022415 viral process • protein acetylation • Сигнальний шлях Notch • cellular response to UV • protein stabilization • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • нейробіологія розвитку • regulation of autophagy • regulation of androgen receptor signaling pathway • positive regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • fat cell differentiation • positive regulation by host of viral transcription • megakaryocyte development • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • internal protein amino acid acetylation • regulation of cell cycle • regulation of tubulin deacetylation • GO:1901313 positive regulation of gene expression • histone H4 acetylation • regulation of cellular response to heat • transcription-coupled nucleotide-excision repair • skeletal muscle tissue development • positive regulation of type I interferon production • response to estrogen • response to hypoxia • regulation of signal transduction by p53 class mediator • internal peptidyl-lysine acetylation • beta-catenin-TCF complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • macrophage derived foam cell differentiation • циркадний ритм • protein deubiquitination • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein destabilization • regulation of megakaryocyte differentiation • histone acetylation • epigenetic maintenance of chromatin in transcription-competent conformation • peptidyl-lysine propionylation • peptidyl-lysine crotonylation • peptidyl-lysine butyrylation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PBB_GE_EP300_213579_s_at_fs.png/250px-PBB_GE_EP300_213579_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/4/42/PBB_GE_EP300_202221_s_at_fs.png/250px-PBB_GE_EP300_202221_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | |
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Локус (UCSC) | Хр. 22: 41.09 – 41.18 Mb | Хр. 15: 81.47 – 81.54 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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