| HDAC9 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Ідентифікатори |
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| Символи | HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, histone deacetylase 9 |
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| Зовнішні ІД | OMIM: 606543 MGI: 1931221 HomoloGene: 128578 GeneCards: HDAC9 |
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| Пов'язані генетичні захворювання |
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| ожиріння, інсульт, неспецифічний виразковий коліт, цереброваскулярні хвороби[1] |
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| Реагує на сполуку |
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| belinostat, entinostat, givinostat, panobinostat, quisinostat, romidepsin, trichostatin A, золінза[2] |
| Онтологія гена |
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| Молекулярна функція | • NAD-dependent histone deacetylase activity (H3-K14 specific)
• GO:0001106 transcription corepressor activity
• histone deacetylase activity
• protein deacetylase activity
• transcription factor binding
• histone deacetylase binding
• зв'язування з іоном металу
• GO:0001948, GO:0016582 protein binding
• hydrolase activity
• protein kinase C binding
• histone deacetylase activity (H4-K16 specific)
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| Клітинна компонента | • цитоплазма
• histone deacetylase complex
• transcription regulator complex
• нуклеоплазма
• клітинне ядро
• histone methyltransferase complex
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| Біологічний процес | • histone H3 deacetylation
• peptidyl-lysine deacetylation
• GO:0009373 regulation of transcription, DNA-templated
• positive regulation of cell migration involved in sprouting angiogenesis
• response to amphetamine
• GO:1901227 negative regulation of transcription by RNA polymerase II
• regulation of striated muscle cell differentiation
• transcription, DNA-templated
• B cell activation
• heart development
• histone H4 deacetylation
• neuron differentiation
• cellular response to insulin stimulus
• regulation of skeletal muscle fiber development
• B cell differentiation
• inflammatory response
• GO:0045996 negative regulation of transcription, DNA-templated
• GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization
• histone deacetylation
• cholesterol homeostasis
• negative regulation of lipoprotein lipase activity
• histone H4-K16 deacetylation
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| Джерела:Amigo / QuickGO | |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | NM_001204144
NM_001204145
NM_001204146
NM_001204147
NM_001204148
| NM_014707
NM_058176
NM_058177
NM_178423
NM_178425
NM_001321868
NM_001321869
NM_001321870
NM_001321871
NM_001321872
NM_001321873
NM_001321874
NM_001321875
NM_001321876
NM_001321877
NM_001321878
NM_001321879
NM_001321884
NM_001321885
NM_001321886
NM_001321887
NM_001321888
NM_001321889
NM_001321890
NM_001321891
NM_001321893
NM_001321894
NM_001321895
NM_001321896
NM_001321897
NM_001321898
NM_001321899
NM_001321900
NM_001321901
NM_001321902 |
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| RefSeq (білок) | NP_001191073
NP_001191074
NP_001191075
NP_001191076
NP_001191077
| NP_001308797
NP_001308798
NP_001308799
NP_001308800
NP_001308801
NP_001308802
NP_001308803
NP_001308804
NP_001308805
NP_001308806
NP_001308807
NP_001308808
NP_001308813
NP_001308814
NP_001308815
NP_001308816
NP_001308817
NP_001308818
NP_001308819
NP_001308820
NP_001308822
NP_001308823
NP_001308824
NP_001308825
NP_001308826
NP_001308827
NP_001308828
NP_001308829
NP_001308830
NP_001308831
NP_055522
NP_478056
NP_848510
NP_848512 |
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| Локус (UCSC) | Хр. 7: 18.09 – 19 Mb | Хр. 12: 34.1 – 34.97 Mb |
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| PubMed search | [3] | [4] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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