HDAC9 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | | |
Ідентифікатори |
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Символи | HDAC9, HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR, histone deacetylase 9 |
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Зовнішні ІД | OMIM: 606543 MGI: 1931221 HomoloGene: 128578 GeneCards: HDAC9 |
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Пов'язані генетичні захворювання |
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ожиріння, інсульт, неспецифічний виразковий коліт, цереброваскулярні хвороби[1] |
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Реагує на сполуку |
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belinostat, entinostat, givinostat, panobinostat, quisinostat, romidepsin, trichostatin A, золінза[2] |
Онтологія гена |
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Молекулярна функція | • NAD-dependent histone deacetylase activity (H3-K14 specific) • GO:0001106 transcription corepressor activity • histone deacetylase activity • protein deacetylase activity • transcription factor binding • histone deacetylase binding • зв'язування з іоном металу • GO:0001948, GO:0016582 protein binding • hydrolase activity • protein kinase C binding • histone deacetylase activity (H4-K16 specific) |
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Клітинна компонента | • цитоплазма • histone deacetylase complex • transcription regulator complex • нуклеоплазма • клітинне ядро • histone methyltransferase complex |
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Біологічний процес | • histone H3 deacetylation • peptidyl-lysine deacetylation • GO:0009373 regulation of transcription, DNA-templated • positive regulation of cell migration involved in sprouting angiogenesis • response to amphetamine • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of striated muscle cell differentiation • transcription, DNA-templated • B cell activation • heart development • histone H4 deacetylation • neuron differentiation • cellular response to insulin stimulus • regulation of skeletal muscle fiber development • B cell differentiation • inflammatory response • GO:0045996 negative regulation of transcription, DNA-templated • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • histone deacetylation • cholesterol homeostasis • negative regulation of lipoprotein lipase activity • histone H4-K16 deacetylation |
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Джерела:Amigo / QuickGO | |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_001204144 NM_001204145 NM_001204146 NM_001204147 NM_001204148
| NM_014707 NM_058176 NM_058177 NM_178423 NM_178425 NM_001321868 NM_001321869 NM_001321870 NM_001321871 NM_001321872 NM_001321873 NM_001321874 NM_001321875 NM_001321876 NM_001321877 NM_001321878 NM_001321879 NM_001321884 NM_001321885 NM_001321886 NM_001321887 NM_001321888 NM_001321889 NM_001321890 NM_001321891 NM_001321893 NM_001321894 NM_001321895 NM_001321896 NM_001321897 NM_001321898 NM_001321899 NM_001321900 NM_001321901 NM_001321902 |
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RefSeq (білок) | NP_001191073 NP_001191074 NP_001191075 NP_001191076 NP_001191077
| NP_001308797 NP_001308798 NP_001308799 NP_001308800 NP_001308801 NP_001308802 NP_001308803 NP_001308804 NP_001308805 NP_001308806 NP_001308807 NP_001308808 NP_001308813 NP_001308814 NP_001308815 NP_001308816 NP_001308817 NP_001308818 NP_001308819 NP_001308820 NP_001308822 NP_001308823 NP_001308824 NP_001308825 NP_001308826 NP_001308827 NP_001308828 NP_001308829 NP_001308830 NP_001308831 NP_055522 NP_478056 NP_848510 NP_848512 |
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Локус (UCSC) | Хр. 7: 18.09 – 19 Mb | Хр. 12: 34.1 – 34.97 Mb |
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PubMed search | [3] | [4] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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