| NLRP3 |
|---|
 |
| Наявні структури |
|---|
| PDB | Пошук ортологів: PDBe RCSB |
|---|
| Список кодів PDB | | 3QF2, 2NAQ | | |
| Ідентифікатори |
|---|
| Символи | NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1, NLR family, pyrin domain containing 3, NLR family pyrin domain containing 3, DFNA34, KEFH |
|---|
| Зовнішні ІД | OMIM: 606416 MGI: 2653833 HomoloGene: 3600 GeneCards: NLRP3 |
|---|
| |
| Пов'язані генетичні захворювання |
|---|
| Muckle-Wells syndrome, CINCA syndrome, autosomal dominant nonsyndromic deafness 34, familial cold autoinflammatory syndrome 4[1] |
| Онтологія гена |
|---|
| Молекулярна функція | • sequence-specific DNA binding
• nucleotide binding
• transcription factor binding
• GO:0001948, GO:0016582 protein binding
• peptidoglycan binding
• ATP binding
• identical protein binding
|
|---|
| Клітинна компонента | • цитоплазма
• гіалоплазма
• extracellular region
• ендоплазматичний ретикулум
• inflammasome complex
• клітинне ядро
• NLRP3 inflammasome complex
• Golgi membrane
• комплекс Ґольджі
• мембрана
|
|---|
| Біологічний процес | • defense response
• detection of biotic stimulus
• NLRP3 inflammasome complex assembly
• GO:0009373 regulation of transcription, DNA-templated
• negative regulation of acute inflammatory response
• positive regulation of interleukin-5 production
• interleukin-18 production
• процес імунної системи
• positive regulation of interleukin-4 production
• transcription, DNA-templated
• positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
• positive regulation of interleukin-13 production
• positive regulation of T-helper 17 cell differentiation
• defense response to virus
• protein complex oligomerization
• positive regulation of T-helper 2 cell differentiation
• regulation of inflammatory response
• interleukin-1 beta production
• positive regulation of type 2 immune response
• inflammatory response
• negative regulation of NF-kappaB transcription factor activity
• activation of cysteine-type endopeptidase activity involved in apoptotic process
• negative regulation of inflammatory response
• cellular response to lipopolysaccharide
• positive regulation of T-helper 2 cell cytokine production
• GO:0072468 сигнальна трансдукція
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• GO:0097285 апоптоз
• вроджений імунітет
• protein deubiquitination
• GO:0051637 defense response to Gram-positive bacterium
• positive regulation of NF-kappaB transcription factor activity
• cellular response to peptidoglycan
• negative regulation of NIK/NF-kappaB signaling
|
|---|
| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
|---|
 |
| Більше даних |
| Ортологи |
|---|
| Види | Людина | Миша |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (мРНК) | NM_001079821
NM_001127461
NM_001127462
NM_001243133
NM_004895
| | NM_183395 |
| |
|---|
| RefSeq (білок) | NP_001073289
NP_001120933
NP_001120934
NP_001230062
NP_004886
| | NP_899632 |
| |
|---|
| Локус (UCSC) | Хр. 1: 247.42 – 247.45 Mb | Хр. 11: 59.43 – 59.46 Mb |
|---|
| PubMed search | [2] | [3] |
|---|
| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
|
