SMAD2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Protein_SMAD2_PDB_1dev.png/250px-Protein_SMAD2_PDB_1dev.png) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1DEV, 1KHX, 1U7V, 2LB3 | | |
Ідентифікатори |
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Символи | SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2, LDS6, CHTD8 |
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Зовнішні ІД | OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2 |
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Онтологія гена |
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Молекулярна функція | • phosphatase binding • I-SMAD binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • R-SMAD binding • co-SMAD binding • transcription factor binding • зв'язування з іоном металу • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • chromatin binding • GO:0001948, GO:0016582 protein binding • double-stranded DNA binding • SMAD binding • DNA binding • protein heterodimerization activity • ubiquitin protein ligase binding • primary miRNA binding • disordered domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • tau protein binding |
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Клітинна компонента | • цитоплазма • гіалоплазма • клітинне ядро • heteromeric SMAD protein complex • SMAD protein complex • transcription regulator complex • внутрішньоклітинний • нуклеоплазма • activin responsive factor complex • GO:0009327 protein-containing complex |
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Біологічний процес | • pattern specification process • ureteric bud development • endoderm development • response to cholesterol • organ growth • embryonic pattern specification • zygotic specification of dorsal/ventral axis • post-embryonic development • protein phosphorylation • pericardium development • regulation of binding • transforming growth factor beta receptor signaling pathway • negative regulation of cell population proliferation • cell fate commitment • common-partner SMAD protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • SMAD protein signal transduction • lung development • signal transduction involved in regulation of gene expression • insulin secretion • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • nodal signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • pancreas development • endoderm formation • activin receptor signaling pathway • SMAD protein complex assembly • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • embryonic foregut morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • response to glucose • positive regulation of epithelial to mesenchymal transition • developmental growth • гаструляція • GO:1990744, GO:1990729 primary miRNA processing • positive regulation of BMP signaling pathway • embryonic cranial skeleton morphogenesis • GO:0045996 negative regulation of transcription, DNA-templated • paraxial mesoderm morphogenesis • GO:0007243 intracellular signal transduction • somatic stem cell population maintenance • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • GO:1901313 positive regulation of gene expression • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • transcription by RNA polymerase II • protein deubiquitination • Загоєння ран • adrenal gland development • secondary palate development |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/6/64/PBB_GE_SMAD2_203075_at_fs.png/250px-PBB_GE_SMAD2_203075_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/3/3f/PBB_GE_SMAD2_203076_s_at_fs.png/250px-PBB_GE_SMAD2_203076_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/6/6a/PBB_GE_SMAD2_203077_s_at_fs.png/250px-PBB_GE_SMAD2_203077_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_001003652 NM_001135937 NM_005901 |
| | NM_001252481 NM_010754 NM_001311070 |
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RefSeq (білок) | | NP_001003652 NP_001129409 NP_005892 |
| | NP_001239410 NP_001297999 NP_034884 |
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Локус (UCSC) | Хр. 18: 47.81 – 47.93 Mb | Хр. 18: 76.37 – 76.44 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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