甘油-3-磷酸脱氢酶 (NAD+) |
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人源甘油-3-磷酸脱氢酶1(PDB 1x0v) |
命名 | 系统命名 | sn-glycerol-3-phosphate:NAD+ 2-oxidoreductase | 缩写 | GPD | 别名 | α-glycerol phosphate dehydrogenase (NAD); α-glycerophosphate dehydrogenase (NAD); glycerol 1-phosphate dehydrogenase; glycerol phosphate dehydrogenase (NAD); glycerophosphate dehydrogenase (NAD); hydroglycerophosphate dehydrogenase; L-α-glycerol phosphate dehydrogenase; L-α-glycerophosphate dehydrogenase; L-glycerol phosphate dehydrogenase; L-glycerophosphate dehydrogenase; NAD-α-glycerophosphate dehydrogenase; NAD-dependent glycerol phosphate dehydrogenase; NAD-dependent glycerol-3-phosphate dehydrogenase; NAD-L-glycerol-3-phosphate dehydrogenase; NAD-linked glycerol 3-phosphate dehydrogenase; NADH-dihydroxyacetone phosphate reductase; glycerol-3-phosphate dehydrogenase (NAD) | |
识别码 |
EC編號 | 1.1.1.8 |
CAS号 | 9075-65-4 |
数据库 |
IntEnz | IntEnz浏览 |
BRENDA(英语:BRENDA) | BRENDA入口 |
ExPASy(英语:ExPASy) | NiceZyme浏览 |
KEGG | KEGG入口 |
MetaCyc(英语:MetaCyc) | 代谢路径 |
PRIAM(英语:PRIAM_enzyme-specific_profiles) | 概述 |
PDB | RCSB PDB PDBj PDBe PDBsum |
基因本体 | AmiGO / EGO |
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甘油-3-磷酸脱氢酶 (NAD+)(英語:glycerol-3-phosphate dehydrogenase (NAD+),EC 1.1.1.8 (页面存档备份,存于互联网档案馆))是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应:
- sn-甘油-3-磷酸 + NAD+
磷酸甘油酮 + NADH + H+
甘油-3-磷酸脱氢酶 (NAD+)主要参与甘油磷酸脂的代谢过程。
参考文献
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.). The Enzymes 7 2nd. New York: Academic Press. 1963: 85–96.
- Brosemer RW, Kuhn RW. Comparative structural properties of honeybee and rabbit alpha-glycerophosphate dehydrogenases. Biochemistry. 1969, 8 (5): 2095–105. PMID 4307630. doi:10.1021/bi00833a047.
- O'Brien SJ, MacIntyre RJ. The -glycerophosphate cycle in Drosophila melanogaster. I Biochemical and developmental aspects. Biochem. Genet. 1972, 7 (2): 141–61. PMID 4340553. doi:10.1007/BF00486085.
- Warkentin DL, Fondy TP. Isolation and characterization of cytoplasmic L-glycerol-3-phosphate dehydrogenase from rabbit-renal-adipose tissue and its comparison with the skeletal-muscle enzyme. Eur. J. Biochem. 1973, 36 (1): 97–109. PMID 4200180. doi:10.1111/j.1432-1033.1973.tb02889.x.
- Albertyn J, van Tonder A, Prior BA. Purification and characterization of glycerol-3-phosphate dehydrogenase of Saccharomyces cerevisiae. FEBS. Lett. 1992, 308 (2): 130–2. PMID 1499720. doi:10.1016/0014-5793(92)81259-O.
- Koekemoer TC, Litthauer D, Oelofsen W. Isolation and characterization of adipose tissue glycerol-3-phosphate dehydrogenase. Int. J. Biochem. Cell. Biol. 1995, 27 (6): 625–32. PMID 7671141. doi:10.1016/1357-2725(95)00012-E.
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| 1.1.1:以NAD或NADP为受体 | |
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| 1.1.2:以细胞色素为受体 | D-乳酸盐脱氢酶 (细胞色素) · D-乳酸盐脱氢酶 (细胞色素c-553) · 甘露醇脱氢酶 (细胞色素) |
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| 1.1.3:以 氧气为受体 | |
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| 1.1.4:以二硫化物为受体 | 维生素K环氧化物还原酶 · 维生素K环氧化物还原酶 (对华法林不敏感) |
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| 1.1.5:以醌类似化合物为受体 | 醌蛋白葡萄糖脱氢酶 |
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| 1.1.99:以其他物质为受体 | 胆碱脱氢酶 · L-2-羟基戊二酸脱氢酶 |
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| EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5/99 · 6.1-3(英语:Template:Ligases CO CS and CN)/4/5-6 |
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