BRCA1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/e/e1/Protein_BRCA1_PDB_1jm7.png/250px-Protein_BRCA1_PDB_1jm7.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1JM7、1JNX、1N5O、1OQA、1T15、1T29、1T2U、1T2V、1Y98、2ING、3COJ、3K0H、3K0K、3K15、3PXA、3PXB、3PXC、3PXD、3PXE、4IFI、4IGK、4JLU、4OFB、4U4A、4Y18、4Y2G |
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識別號 |
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别名 | BRCA1;, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes |
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外部ID | OMIM:113705 MGI:104537 HomoloGene:5276 GeneCards:BRCA1 |
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相關疾病 |
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BRCA1 hereditary breast and ovarian cancer syndrome、breast carcinoma、泌尿生殖肿瘤、卵巢腫瘤、hereditary breast ovarian cancer[1] |
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基因位置(小鼠) |
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![小鼠11号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | 染色体 | 小鼠11号染色体[3] |
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| 基因座 | 11 65.18 cM|11 D | 起始 | 101,379,590 bp[3] |
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终止 | 101,442,781 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/a/ad/PBB_GE_BRCA1_204531_s_at_fs.png/250px-PBB_GE_BRCA1_204531_s_at_fs.png)
![](//upload.wikimedia.org/wikipedia/commons/thumb/0/0f/PBB_GE_BRCA1_211851_x_at_fs.png/250px-PBB_GE_BRCA1_211851_x_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • tubulin binding • 金屬離子結合 • 酶结合 • 鋅離子結合 • damaged DNA binding • 血浆蛋白结合 • 转录共激活因子活性 • 雄激素受体结合 • RNA binding • 泛素蛋白连接酶结合 • 泛素蛋白轉移酶活性 • DNA结合 • 轉移酶活性 • RNA polymerase binding • 相同蛋白质结合
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細胞組分 | • BRCA1-BARD1 complex • condensed nuclear chromosome • BRCA1-A complex • ubiquitin ligase complex • 细胞膜 • 核质 • condensed chromosome • 細胞質 • 染色体 • 细胞核 • lateral element • 大分子复合体 • 核糖核蛋白
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生物學過程 | • response to ionizing radiation • centrosome cycle • 染色体分离 • protein K6-linked ubiquitination • intrinsic apoptotic signaling pathway in response to DNA damage • 細胞週期 • double-strand break repair via nonhomologous end joining • 细胞凋亡 • regulation of apoptotic process • regulation of gene expression by genetic imprinting • regulation of transcription, DNA-templated • negative regulation of fatty acid biosynthetic process • transcription, DNA-templated • regulation of transcription by RNA polymerase III • fatty acid biosynthetic process • regulation of DNA methylation • negative regulation of intracellular estrogen receptor signaling pathway • protein autoubiquitination • positive regulation of histone H3-K9 methylation • DNA重组 • positive regulation of angiogenesis • response to estrogen • cellular response to indole-3-methanol • 死亡域受体对外源性凋亡信号通路的负调控 • negative regulation of transcription, DNA-templated • positive regulation of protein ubiquitination • androgen receptor signaling pathway • negative regulation of centriole replication • postreplication repair • 脂質代謝 • cellular response to tumor necrosis factor • positive regulation of DNA repair • 脂肪酸代謝 • positive regulation of gene expression • negative regulation of histone H3-K4 methylation • regulation of cell population proliferation • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • positive regulation of transcription by RNA polymerase II • positive regulation of histone H4-K20 methylation • DNA double-strand break processing • double-strand break repair via homologous recombination • negative regulation of histone acetylation • protein ubiquitination • positive regulation of histone H3-K4 methylation • DNA修復 • double-strand break repair • positive regulation of histone acetylation • dosage compensation by inactivation of X chromosome • negative regulation of histone H3-K9 methylation • positive regulation of histone H3-K9 acetylation • positive regulation of transcription, DNA-templated • chordate embryonic development • positive regulation of histone H4-K16 acetylation • cellular response to DNA damage stimulus • protein deubiquitination • 脫氧核糖核酸複製 • mitotic G2/M transition checkpoint • regulation of transcription by RNA polymerase II • negative regulation of G0 to G1 transition • transcription by RNA polymerase II • mitotic G2 DNA damage checkpoint signaling • regulation of signal transduction by p53 class mediator
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | NM_007294 NM_007295 NM_007296 NM_007297 NM_007298
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NM_007299 NM_007300 NM_007301 NM_007302 NM_007303 NM_007305 NM_007306 |
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蛋白序列 | |
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NP_009225 NP_009228 NP_009229 NP_009230 NP_009231 |
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基因位置(UCSC) | Chr 17: 43.04 – 43.17 Mb | Chr 11: 101.38 – 101.44 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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