CD18 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Protein_ITGB2_PDB_1l3y.png/250px-Protein_ITGB2_PDB_1l3y.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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1L3Y、1YUK、2JF1、2P26、2P28、3K6S、3K71、3K72、2V7D、4NEH、4NEN、5E6X、5E6V、5E6S、5E6R、5E6W、5ES4、5E6U |
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識別號 |
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别名 | ITGB2;, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2 |
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外部ID | OMIM:600065 MGI:96611 HomoloGene:20092 GeneCards:ITGB2 |
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相關疾病 |
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leukocyte adhesion deficiency-1[1] |
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基因位置(小鼠) |
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![小鼠10号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | 染色体 | 小鼠10号染色体[3] |
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| 基因座 | 10 C1|10 39.72 cM | 起始 | 77,366,086 bp[3] |
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终止 | 77,401,542 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/PBB_GE_ITGB2_202803_s_at_fs.png/250px-PBB_GE_ITGB2_202803_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • 大分子复合物结合 • 金屬離子結合 • 血浆蛋白结合 • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding • amyloid-beta binding • complement component C3b binding • integrin binding • signaling receptor activity • cargo receptor activity
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細胞組分 | • integral component of membrane • 細胞外囊泡 • integrin alphaL-beta2 complex • 膜 • 细胞膜 • receptor complex • cell surface • integrin complex • 外排體 • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • 粘着斑 • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • 脂筏模型 • cytoplasmic region • 大分子复合体
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生物學過程 | • leukocyte cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • 老化 • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • 細胞粘附 • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • 细胞凋亡 • 吞噬作用 • neutrophil degranulation • microglial cell activation • 受体介导的内吞作用 • phagocytosis, engulfment • 细胞迁移 • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • cell adhesion mediated by integrin • positive regulation of neutrophil degranulation • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of neuron death • positive regulation of microglial cell activation • neutrophil migration • positive regulation of prostaglandin-E synthase activity • positive regulation of leukocyte adhesion to vascular endothelial cell
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | |
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NM_000211 NM_001127491 NM_001303238 |
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蛋白序列 | |
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NP_000202 NP_001120963 NP_001290167 |
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基因位置(UCSC) | Chr 21: 44.89 – 44.93 Mb | Chr 10: 77.37 – 77.4 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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