IDX-184
![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/20px-Star_of_life_caution.svg.png)
![]() | |
法律規範狀態 | |
---|---|
法律規範 |
|
识别信息 | |
| |
CAS号 | 1036915-08-8 ![]() |
PubChem CID |
|
ChemSpider |
|
UNII |
|
化学信息 | |
化学式 | C25H35N6O9PS |
摩尔质量 | 626.6 |
3D模型(JSmol(英语:JSmol)) |
|
| |
|
IDX-184是一种抗病毒药物,开发用作NS5B(英语:NS5B) RNA聚合酶抑制剂来治疗丙型肝炎。[1][2]尽管它在早期臨床試驗中显示出一定效果,但并未通过IIb期试验。[3]然而,该药物的研究仍在继续,并对一些新病毒(如茲卡病毒[4][5]、MERS[6]和SARS-CoV-2等冠状病毒[7][8])显示出一定的药物活性。
参考文献
- ^ Elfiky AA, Elshemey WM. IDX-184 is a superior HCV direct-acting antiviral drug: a QSAR study. Med Chem Res. 2016;25(5):1005-1008. doi:10.1007/s00044-016-1533-y PMID 32214769
- ^ Elfiky AA. Novel Guanosine Derivatives as Anti-HCV NS5b Polymerase: A QSAR and Molecular Docking Study. Med Chem. 2019;15(2):130-137. doi:10.2174/1573406414666181015152511 PMID 30324891
- ^ Gentile I, Buonomo AR, Zappulo E, Borgia G. Discontinued drugs in 2012 - 2013: hepatitis C virus infection. Expert Opin Investig Drugs. 2015 Feb;24(2):239-51. doi:10.1517/13543784.2015.982274 PMID 25384989
- ^ Elfiky AA. Zika viral polymerase inhibition using anti-HCV drugs both in market and under clinical trials. J Med Virol. 2016 Dec;88(12):2044-2051. doi:10.1002/jmv.24678 PMID 27604059
- ^ Elfiky AA, Ismail AM. Molecular docking revealed the binding of nucleotide/side inhibitors to Zika viral polymerase solved structures. SAR QSAR Environ Res. 2018 May;29(5):409-418. doi:10.1080/1062936X.2018.1454981 PMID 29652194
- ^ Elfiky AA, Mahdy SM, Elshemey WM. Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses. J Med Virol. 2017 Jun;89(6):1040-1047. doi:10.1002/jmv.24736 PMID 27864902
- ^ Elfiky AA. Anti-HCV, nucleotide inhibitors, repurposing against COVID-19. Life Sci. 2020 May 1;248:117477. doi:10.1016/j.lfs.2020.117477 PMID 32119961
- ^ Elfiky AA. Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. doi:10.1016/j.lfs.2020.117592 PMID 32222463
|