SIRT1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/98/SIRTUIN1.png/250px-SIRTUIN1.png) |
已知的結構 |
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PDB | 直系同源搜索: PDBe RCSB |
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PDBID列表 |
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4I5I、4IF6、4IG9、4KXQ、4ZZH、4ZZI、4ZZJ、5BTR |
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識別號 |
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别名 | SIRT1;, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1 |
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外部ID | OMIM:604479 MGI:2135607 HomoloGene:56556 GeneCards:SIRT1 |
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為以下藥物的標靶 |
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SRT-1720[1] |
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基因位置(小鼠) |
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![小鼠10号染色体](//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/260px-Ideogram_house_mouse_chromosome_10.svg.png) | 染色体 | 小鼠10号染色体[3] |
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| 基因座 | 10|10 B4 | 起始 | 63,154,784 bp[3] |
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终止 | 63,217,483 bp[3] |
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RNA表达模式 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/09/PBB_GE_SIRT1_218878_s_at_fs.png/250px-PBB_GE_SIRT1_218878_s_at_fs.png) |
查阅更多表达数据 |
基因本體 |
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分子功能 | • transcription corepressor activity • protein domain specific binding • core promoter sequence-specific DNA binding • protein C-terminus binding • keratin filament binding • 转录因子结合 • 金屬離子結合 • HLH domain binding • 酶结合 • protein deacetylase activity • histone binding • 血浆蛋白结合 • NAD-dependent histone deacetylase activity • NAD-dependent protein deacetylase activity • histone deacetylase activity • p53 binding • mitogen-activated protein kinase binding • deacetylase activity • bHLH transcription factor binding • NAD+ binding • 相同蛋白质结合 • NAD+ ADP-ribosyltransferase activity • 水解酶活性 • NAD-dependent histone deacetylase activity (H3-K9 specific) • DNA-binding transcription activator activity, RNA polymerase II-specific
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細胞組分 | • 細胞質 • nuclear envelope • rDNA heterochromatin • chromatin silencing complex • 線粒體 • 细胞核 • ESC/E(Z) complex • 核仁 • 染色质 • 核质 • PML body • 內膜 • 细胞质基质
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生物學過程 | • cellular triglyceride homeostasis • positive regulation of MHC class II biosynthetic process • DNA synthesis involved in DNA repair • positive regulation of protein phosphorylation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • rhythmic process • single strand break repair • muscle organ development • histone H3-K9 deacetylation • negative regulation of cellular response to testosterone stimulus • regulation of peroxisome proliferator activated receptor signaling pathway • cellular response to DNA damage stimulus • regulation of bile acid biosynthetic process • 脫氧核糖核酸複製 • negative regulation of TOR signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of glucose metabolic process • rDNA heterochromatin assembly • negative regulation of DNA damage response, signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • 昼夜节律 • positive regulation of cellular senescence • 精子发生 • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to ionizing radiation • negative regulation of helicase activity • cholesterol homeostasis • response to leptin • cellular response to hypoxia • triglyceride mobilization • negative regulation of prostaglandin biosynthetic process • proteasome-mediated ubiquitin-dependent protein catabolic process • 细胞凋亡 • peptidyl-lysine deacetylation • negative regulation of fat cell differentiation • negative regulation of peptidyl-lysine acetylation • regulation of transcription, DNA-templated • positive regulation of adaptive immune response • stress-induced premature senescence • negative regulation of androgen receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • response to oxidative stress • negative regulation of DNA-binding transcription factor activity • negative regulation of gene expression • transcription, DNA-templated • negative regulation of cAMP-dependent protein kinase activity • pyrimidine dimer repair by nucleotide-excision repair • response to insulin • histone H3-K9 modification • positive regulation of macroautophagy • positive regulation of cholesterol efflux • protein ubiquitination • negative regulation of cell growth • positive regulation of macrophage apoptotic process • rRNA processing • regulation of brown fat cell differentiation • negative regulation of phosphorylation • viral process • DNA修復 • negative regulation of neuron death • positive regulation of histone H3-K9 methylation • negative regulation of histone H3-K14 acetylation • negative regulation of protein kinase B signaling • 细胞分化 • ovulation from ovarian follicle • regulation of protein serine/threonine kinase activity • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • protein ADP-ribosylation • leptin-mediated signaling pathway • negative regulation of apoptotic process • negative regulation of transcription by RNA polymerase II • chromatin organization • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • protein deacetylation • fatty acid homeostasis • protein destabilization • regulation of mitotic cell cycle • positive regulation of cAMP-dependent protein kinase activity • white fat cell differentiation • positive regulation of insulin receptor signaling pathway • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • peptidyl-lysine acetylation • response to hydrogen peroxide • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of histone H4-K16 acetylation • positive regulation of endothelial cell proliferation • regulation of smooth muscle cell apoptotic process • behavioral response to starvation • cellular glucose homeostasis • cellular response to starvation • cellular response to tumor necrosis factor • positive regulation of DNA repair • multicellular organism development • regulation of cell population proliferation • positive regulation of cell population proliferation • regulation of endodeoxyribonuclease activity • regulation of cellular response to heat • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • UV-damage excision repair • histone deacetylation • positive regulation of transcription by RNA polymerase II • 血管新生 • macrophage cytokine production • regulation of lipid storage • positive regulation of adipose tissue development • macrophage differentiation • transcription by RNA polymerase II • positive regulation of smooth muscle cell differentiation • negative regulation of histone H3-K9 trimethylation • positive regulation of apoptotic process • cellular response to hydrogen peroxide • histone H3 deacetylation • negative regulation of protein acetylation • regulation of apoptotic process • cellular response to leukemia inhibitory factor • positive regulation of angiogenesis • transforming growth factor beta receptor signaling pathway • positive regulation of blood vessel endothelial cell migration • negative regulation of cellular senescence
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Sources:Amigo / QuickGO |
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直系同源 |
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物種 | 人類 | 小鼠 |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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mRNA序列 | |
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NM_001142498 NM_001314049 NM_012238 |
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NM_001159589 NM_001159590 NM_019812 |
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蛋白序列 | |
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NP_001135970 NP_001300978 NP_036370 |
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基因位置(UCSC) | Chr 10: 67.88 – 67.92 Mb | Chr 10: 63.15 – 63.22 Mb |
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PubMed查找 | [4] | [5] |
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維基數據 |
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