Protein encoded by the GRAMD2B gene
GRAMD2B |
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Identifiers |
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Aliases | GRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B |
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External IDs | MGI: 1914815; HomoloGene: 32570; GeneCards: GRAMD2B; OMA:GRAMD2B - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 5 (human)[1] |
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| Band | 5q23.2 | Start | 126,360,132 bp[1] |
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End | 126,496,494 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 18 (mouse)[2] |
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| Band | 18|18 D3 | Start | 56,533,409 bp[2] |
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End | 56,636,864 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Achilles tendon
- internal globus pallidus
- corpus callosum
- external globus pallidus
- bronchial epithelial cell
- decidua
- dorsal motor nucleus of vagus nerve
- jejunal mucosa
- Epithelium of choroid plexus
- caudate nucleus
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| Top expressed in | - mucous cell of stomach
- jejunum
- islet of Langerhans
- pyloric antrum
- duodenum
- epithelium of stomach
- parotid gland
- external carotid artery
- internal carotid artery
- left lobe of liver
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001146319 NM_001146320 NM_001146321 NM_001146322 NM_023927
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NM_001349541 NM_001349542 NM_001349543 NM_001349544 |
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RefSeq (protein) | NP_001139791 NP_001139792 NP_001139793 NP_001139794 NP_076416
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NP_001336470 NP_001336471 NP_001336472 NP_001336473 |
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Location (UCSC) | Chr 5: 126.36 – 126.5 Mb | Chr 18: 56.53 – 56.64 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.[5][6]
GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7]
GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.[8][7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
- ^ "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
- ^ a b Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
- ^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.