GRAM domain-containing 2B

Protein encoded by the GRAMD2B gene
GRAMD2B
Identifiers
AliasesGRAMD2B, NS3TP2, GRAMD3, GRAM domain containing 3, GRAM domain containing 2B
External IDsMGI: 1914815; HomoloGene: 32570; GeneCards: GRAMD2B; OMA:GRAMD2B - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for GRAMD2B
Genomic location for GRAMD2B
Band5q23.2Start126,360,132 bp[1]
End126,496,494 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for GRAMD2B
Genomic location for GRAMD2B
Band18|18 D3Start56,533,409 bp[2]
End56,636,864 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • internal globus pallidus

  • corpus callosum

  • external globus pallidus

  • bronchial epithelial cell

  • decidua

  • dorsal motor nucleus of vagus nerve

  • jejunal mucosa

  • Epithelium of choroid plexus

  • caudate nucleus
Top expressed in
  • mucous cell of stomach

  • jejunum

  • islet of Langerhans

  • pyloric antrum

  • duodenum

  • epithelium of stomach

  • parotid gland

  • external carotid artery

  • internal carotid artery

  • left lobe of liver
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

65983

107022

Ensembl

ENSG00000155324

ENSMUSG00000001700

UniProt

Q96HH9

Q6PEM6

RefSeq (mRNA)
NM_001146319
NM_001146320
NM_001146321
NM_001146322
NM_023927

NM_001349541
NM_001349542
NM_001349543
NM_001349544

NM_026240
NM_001360917

RefSeq (protein)
NP_001139791
NP_001139792
NP_001139793
NP_001139794
NP_076416

NP_001336470
NP_001336471
NP_001336472
NP_001336473

NP_080516
NP_001347846

Location (UCSC)Chr 5: 126.36 – 126.5 MbChr 18: 56.53 – 56.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.[5][6]

GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7]

GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.[8][7] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000155324 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001700 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
  6. ^ "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
  7. ^ a b Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
  8. ^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.