Protein encoded by the GRAMD2A gene
GRAMD2A |
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Identifiers |
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Aliases | GRAMD2A, GRAMD2, GRAM domain containing 2A |
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External IDs | MGI: 3528937; HomoloGene: 52791; GeneCards: GRAMD2A; OMA:GRAMD2A - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 15 (human)[1] |
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| Band | 15q23 | Start | 72,159,806 bp[1] |
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End | 72,197,787 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 B | Start | 59,587,427 bp[2] |
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End | 59,626,157 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tibia
- placenta
- right uterine tube
- right lobe of thyroid gland
- left lobe of thyroid gland
- right lung
- olfactory zone of nasal mucosa
- tail of epididymis
- corpus epididymis
- upper lobe of left lung
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| Top expressed in | - layer of retina
- neural layer of retina
- lung
- placenta
- granulocyte
- testicle
- outer nuclear layer
- zone of skin
- secondary oocyte
- jejunum
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol binding
- lipid binding
| Cellular component | - membrane
- integral component of membrane
- intrinsic component of endoplasmic reticulum membrane
- extrinsic component of cytoplasmic side of plasma membrane
- organelle membrane contact site
- endoplasmic reticulum
- endoplasmic reticulum membrane
- plasma membrane
| Biological process | - endoplasmic reticulum-plasma membrane tethering
- regulation of store-operated calcium entry
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001033498 NM_001357686 NM_001379375 NM_001379376 NM_001379377 |
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RefSeq (protein) | | |
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NP_001028670 NP_001344615 NP_001366304 NP_001366305 NP_001366306 |
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Location (UCSC) | Chr 15: 72.16 – 72.2 Mb | Chr 9: 59.59 – 59.63 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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GRAM domain-containing 2A protein (GRAMD2A; formerly GRAMD2) is a protein encoded by the GRAMD2A gene.[5] Like GRAMD2B, the protein consists of a GRAM domain and a transmembrane domain that anchors it to the endoplasmic reticulum.[6][7]
GRAMD2A is a mammalian representative of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[7] It has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2B. Unlike LAM and its paralogs except GRAMD2B, GRAMD2A lacks a VASt domain.
The protein localizes to sites where membranes from different organelles are in close apposition.[7] There, it tethers the endoplasmic reticulum to the plasma membrane through its GRAM domain binding phosphatidylinositol 4,5-bisphosphate in the plasma membrane at sites enriched for the phospholipid.[7] The protein ensures proper stromal interaction molecule 1 (STIM1) recruitment to these sites of membrane contact as part of the store-operated calcium entry pathway – a component of intracellular calcium homeostasis.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175318 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074259 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "GRAMD2A GRAM domain containing 2A [ Homo sapiens (human) ]". Retrieved March 7, 2020.
- ^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.
- ^ a b c d e Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.