Phenindione
Chemical compound
- AU: D
- Passes into breast milk
administration
- B01AA02 (WHO)
- 2-phenyl-1H-indene-1,3(2H)-dione
- 83-12-5 Y
- 4760
- 6838
- DB00498 Y
- 4596 Y
- 5M7Y6274ZE
- D08354 Y
- CHEBI:8066 Y
- ChEMBL711 Y
- DTXSID5023453
- Interactive image
- O=C2c1ccccc1C(=O)C2c3ccccc3
- InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H Y
- Key:NFBAXHOPROOJAW-UHFFFAOYSA-N Y
Phenindione is an anticoagulant which functions as a Vitamin K antagonist.
Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred.[1][2]
References
- ^ Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920. S2CID 17052792.
- ^ Sweetman SC, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. "Phenindione", p. 1369.
External links
- Diseases Database (DDB): 30536
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Glycoprotein IIb/IIIa inhibitors |
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ADP receptor/P2Y12 inhibitors | |
Prostaglandin analogue (PGI2) | |
COX inhibitors | |
Thromboxane inhibitors | |
Phosphodiesterase inhibitors | |
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Vitamin K antagonists (inhibit II, VII, IX, X) | |||||
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Factor Xa inhibitors (with some II inhibition) |
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Direct thrombin (IIa) inhibitors |
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Other |
fibrinolytics
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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