Class of enzymes
phosphoadenylylsulfatase |
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Identifiers |
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EC no. | 3.6.2.2 |
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CAS no. | 37289-37-5 |
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Databases |
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IntEnz | IntEnz view |
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BRENDA | BRENDA entry |
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ExPASy | NiceZyme view |
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KEGG | KEGG entry |
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MetaCyc | metabolic pathway |
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PRIAM | profile |
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PDB structures | RCSB PDB PDBe PDBsum |
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Gene Ontology | AmiGO / QuickGO |
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Search |
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PMC | articles |
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PubMed | articles |
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NCBI | proteins |
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In enzymology, a phosphoadenylylsulfatase (EC 3.6.2.2) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + H2O adenosine 3',5'-bisphosphate + sulfate
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and H2O, whereas its two products are adenosine 3',5'-bisphosphate and sulfate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in sulfonyl-containing anhydrides. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate sulfohydrolase. Other names in common use include 3-phosphoadenylyl sulfatase, 3-phosphoadenosine 5-phosphosulfate sulfatase, PAPS sulfatase, and 3'-phosphoadenylylsulfate sulfohydrolase. This enzyme participates in sulfur metabolism. It employs one cofactor, manganese.
References
- BALASUBRAMANIAN AS, BACHHAWAT BK (1962). "Enzymic degradation of active sulphate". Biochim. Biophys. Acta. 59 (2): 389–97. doi:10.1016/0006-3002(62)90188-9. PMID 13864264.
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