Class of enzymes
Protein-synthesizing GTPase |
---|
Identifiers |
---|
EC no. | 3.6.5.3 |
---|
Databases |
---|
IntEnz | IntEnz view |
---|
BRENDA | BRENDA entry |
---|
ExPASy | NiceZyme view |
---|
KEGG | KEGG entry |
---|
MetaCyc | metabolic pathway |
---|
PRIAM | profile |
---|
PDB structures | RCSB PDB PDBe PDBsum |
---|
Search |
---|
PMC | articles |
---|
PubMed | articles |
---|
NCBI | proteins |
---|
|
Protein-synthesizing GTPases (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation into protein by the ribosome, with systematic name GTP phosphohydrolase (mRNA-translation-assisting).[1][2][3][4][5] They usually include translation initiation factors such as IF-2 and translation elongation factors such as EF-Tu.
References
- ^ Kurzchalia TV, Bommer UA, Babkina GT, Karpova GG (October 1984). "GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2". FEBS Letters. 175 (2): 313–6. doi:10.1016/0014-5793(84)80758-9. PMID 6566615.
- ^ Kisselev LL (1995). "Termination of translation in eukaryotes". Biochemistry and Cell Biology. 73 (11–12): 1079–86. doi:10.1139/o95-116. PMID 8722024.
- ^ Rodnina MV, Savelsbergh A, Katunin VI, Wintermeyer W (January 1997). "Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome". Nature. 385 (6611): 37–41. doi:10.1038/385037a0. PMID 8985244.
- ^ Freistroffer DV, Pavlov MY, MacDougall J, Buckingham RH, Ehrenberg M (July 1997). "Release factor RF3 in E.coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner". The EMBO Journal. 16 (13): 4126–33. doi:10.1093/emboj/16.13.4126. PMC 1170035. PMID 9233821.
- ^ Krab IM, Parmeggiani A (November 1998). "EF-Tu, a GTPase odyssey". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1443 (1–2): 1–22. doi:10.1016/s0167-4781(98)00169-9. PMID 9838020.
External links
- Protein-synthesizing+GTPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Hydrolases: acid anhydride hydrolases (
EC 3.6)
3.6.1 | |
---|
3.6.2 | |
---|
3.6.3-4: ATPase | |
---|
3.6.5: GTPase | |
---|
|
---|
Activity | |
---|
Regulation | |
---|
Classification | |
---|
Kinetics | |
---|
Types | |
---|
Portal:- Biology
This EC 3.6 enzyme-related article is a stub. You can help Wikipedia by expanding it. |