Lavoltidin
(IUPAC) ime | |||
---|---|---|---|
[1-metil-5-({3-[3-(piperidin-1-ilmetil)fenoksi]propil}amino)-1H-1,2,4-triazol-3-il]metanol | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 76956-02-0 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 55473 | ||
ChemSpider[3] | 50093 | ||
UNII | X16K5179V5 | ||
Hemijski podaci | |||
Formula | C19H29N5O2 | ||
Mol. masa | 359,47 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | Uncontrolled | ||
Način primene | Oralno |
Lavoltidin (INN, USAN; AH-23,844, lokstidin) je veoma potentan i selektivan antagonist H2 receptora, koji je bio u razvoju za tretman gastroesofagealne refluksne bolesti, ali je razvoj prekinut zbog otkrića da on proizvodi gastrične karcinoidne tumore kod glodara.[4][5]
Povezano
- Antagonist H2 receptora
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Washington, Neena (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7.
- ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
Literatura
- Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
- Washington, Neena (1991). Antacids and anti-reflux agents. Boca Raton: CRC Press. ISBN 0-8493-5444-7.
Spoljašnje veze
Portal Medicina | |
Portal Hemija |
- p
- r
- u
Inhibitori: Aminoguanidin |
Histamin; Prekursori: L-Histidin; Kofaktori: Vitamin B6 |