ZM-241,385
ZM-241,385 | |||
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IUPAC ime |
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Identifikacija | |||
CAS registarski broj | 139180-30-6 ![]() | ||
PubChem[1][2] | 176407 | ||
ChemSpider[3] | 153646 ![]() | ||
ChEMBL[4] | CHEMBL1628689 ![]() | ||
IUPHAR ligand | 405 | ||
Jmol-3D slike | Slika 1 | ||
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Svojstva | |||
Molekulska formula | C16H15N7O2 | ||
Molarna masa | 337.34 g mol−1 | ||
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
Infobox references |
ZM-241,385 je antagonist visokog afiniteta koji je selektivan za adenosinski A2A receptor.[5]
U životinjskim modelima je pokazano da ZM-241,385 pruža zaštitu protiv beta amiloidne neurotoksičnosti i da stoga može da bude koristan u tretmanu Alchajmerove bolesti.[6]ZM-241,385 isto tako povećava otpuštanje dopamina izvedenog iz L-DOPA i stoga je koristan u tretmanu Parkinsonove bolesti.[7]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Palmer TM, Poucher SM, Jacobson KA, Stiles GL (December 1995). „125I-4-(2-(7-amino-2-(2-furyl)(1,2,4)triazolo(2,3-a)(1,3,5) triazin-5-yl-amino)ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptor”. Molecular Pharmacology 48 (6): 970-4. PMID 8848012. Arhivirano iz originala na datum 2008-09-07. Pristupljeno 2014-04-11.
- ↑ Dall'Igna OP, Porciúncula LO, Souza DO, Cunha RA, Lara DR, Dall'lgna OP (April 2003). „Neuroprotection by caffeine and adenosine A2A receptor blockade of beta-amyloid neurotoxicity”. British Journal of Pharmacology 138 (7): 1207-9. DOI:10.1038/sj.bjp.0705185. PMC 1573785. PMID 12711619.
- ↑ Gołembiowska K, Dziubina A (September 2004). „Striatal adenosine A(2A) receptor blockade increases extracellular dopamine release following l-DOPA administration in intact and dopamine-denervated rats”. Neuropharmacology 47 (3): 414-26. DOI:10.1016/j.neuropharm.2004.04.018. PMID 15275831.
Spoljašnje veze
![]() | Portal Hemija |
MeSH ZM+241385
- p
- r
- u
2-(1-Heksinil)-N-metiladenozin • 2-Cl-IB-MECA • 2'-MeCCPA • 5'-N-etilkarboksamidoadenozin • ATL-146e • BAY 60-6583 • CCPA • CGS-21680 • CP-532,903 • GR 79236 • LUF-5835 • LUF-5845 • N6-Ciklopentiladenozin • Regadenoson • SDZ WAG 994 • UK-432,097 | |
Antagonisti | 8-Fenil-1,3-dipropilksantin • Acefilin • Aminofilin • Bamifilin • Kofein • CGS-15943 • 8-Hloroteofilin • CPX • CVT-6883 • Dimetazan • DPCPX • Fenetilin • Istradefilin • KF-26777 • MRE3008F20 • MRS-1220 • MRS-1334 • MRS-1706 • MRS-1754 • MRS-3777 • Paraksantin • Pentoksifilin • Preladenant • Propentofilin • PSB-10 • PSB-11 • PSB 36 • PSB-603 • PSB-788 • PSB-1115 • Rolofilin • SCH-442,416 • SCH-58261 • Teobromin • Teofilin • VUF-5574 • ZM-241,385 |
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