CORO6

CORO6
Identifiers
Aliases	CORO6, coronin 6
External IDs	MGI: 2183448; HomoloGene: 104099; GeneCards: CORO6; OMA:CORO6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 29,614,756 bp[1] End 29,622,907 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 77,353,237 bp[2] End 77,361,310 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh gastric mucosa apex of heart Skeletal muscle tissue of rectus abdominis left lobe of thyroid gland right auricle right lobe of thyroid gland quadriceps femoris muscle vastus lateralis muscle Top expressed in interventricular septum soleus muscle muscle of thigh extraocular muscle digastric muscle myocardium of ventricle right ventricle cardiac muscles sternocleidomastoid muscle intercostal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding protein binding Cellular component actin cytoskeleton Biological process actin cytoskeleton organization actin filament organization cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84940 216961 Ensembl ENSG00000167549 ENSMUSG00000020836 UniProt Q6QEF8 Q920M5 RefSeq (mRNA) NM_032854 NM_001351301 NM_001351302 NM_139128 NM_139129 NM_139130 NM_001368670 RefSeq (protein) NP_116243 NP_001338230 NP_001338231 NP_624354 NP_624355 NP_624356 NP_001355599 Location (UCSC) Chr 17: 29.61 – 29.62 Mb Chr 11: 77.35 – 77.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coronin-6 also known as coronin-like protein E (Clipin-E) is a protein that in humans is encoded by the CORO6 gene.

Coronin-6 belongs to the coronin family which is an actin binding protein.^[5][6] Human CORO6 gene is located on chromosome 17 on the cytogenetic band 17 p11.2.^[7] Gene CORO6 is well conserved across domain of eukaryotic organisms from animal to fungi.^[8]

Based on the EST profile, CORO6 expressed in high level at the larynx, nerve and muscle. CORO6 has also been shown to be expressed in high levels in the breast (mammary gland) tumor. During the human development stage, the higher level of CORO6 expressed at blastocyst and adult.^[9]

Alternative mRNAs are shown aligned from 5' to 3' on a virtual genome where introns have been shrunk to a minimal length. Exon size is proportional to length, intron height reflects the number of cDNAs supporting each intron. Introns of the same color are identical, of different colors are different. 'Good proteins' are pink, partial or not-good proteins are yellow, uORFs are green. 5' cap or3' poly A flags show completeness of the transcript . CORO6 contains 21 distinct gt-ag introns. Transcription produces 10 alternatively spliced mRNA. There are 3 probable alternative promoters, and validated alternative polyadenylation sites.^[10]

CORO6 protein sequence contains WD-40 repeats. WD40 domain is a structural motif found in Eukaryotes and cover variety of functions, such as adaptor or regulatory modules in signal transduction, pre-mRNA processing and cytoskeletal assembly. It usually terminating at WD dipeptide at its C-terminus and is about 40 residues long, so called WD40.^[11]

The structure of CORO6 is predicted by using Phyre2 program. It is similar to the crystal structure of murine coronin-1. 390 residues ( 83% of CORO6 protein sequence) have been modelled with 100.0% confidence by the single highest scoring template. Image coloured by rainbow N → C terminus

Human proteins which are the paralogs to CORO6, CORO1A, CORO1B, CORO1C, CORO2A, CORO2B, CORO7

The table compared Homo sapiens protein CORO6 to its paralogs

By comparing its paralogs we found that CORO1A and CORO1B are most related to CORO6.

CORO6 is highly conserved throughout the organisms from vertebrate to fungus, the organisms listed in the table are some representatives.

There are several clinical studies about that have been performed by using microarray indicating that CORO6 is positively related to allergic nasal epithelium response to house dust mite allergen in vitro.^[12]

• Human CORO6 genome location and CORO6 gene details page in the UCSC Genome Browser.