Renzaprid
(IUPAC) ime | |||
---|---|---|---|
4-amino-N-[(4S,5S)-1-azabiciklo[3.3.1]non-4-il]-5-hloro-2-metoksibenzamid | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 109872-41-5 | ||
ATC kod | nije dodeljen | ||
PubChem[1][2] | 3086547 | ||
ChemSpider[3] | 16736758 | ||
UNII | 9073C0W4E9 Y | ||
ChEMBL[4] | CHEMBL289753 Y | ||
Hemijski podaci | |||
Formula | C16H22ClN3O2 | ||
Mol. masa | 323,818 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status |
Renzaprid je gastroprokinetički agens i antiemetik koji deluje kao pun 5-HT4 pun agonist i 5-HT3 antagonist.[5][6] On takođe funkcioniše kao 5-HT2B antagonist i ima isti afinitet za 5-HT2A i 5-HT2C receptore, mada je malo verovatno da oni doprinose njegovom terapeutskom dejstvu.[5]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ 5,0 5,1 Meyers NL, Hickling RI. (2008). „Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome.”. Drugs R D. 9 (1): 37–63. PMID 18095752.
- ↑ Camilleri M., McKinzie S., Fox J., Foxx-Orenstein A., Burton D., Thomforde G., Baxter K. and Zinsmeister A. R. (2004). "Effect of Renzapride on Transit in Constipation-Predominant Irritable Bowel Syndrome", Clin. Gastroent. and Hepatology; 2:895-904
Spoljašnje veze
Portal Medicina | |
Portal Hemija |
- p
- r
- u
Alosetron • Azasetron • Bemesetron • Cilansetron • Klozapin • Dazoprid • Dolasetron • Granisetron • Lerisetron • Metoklopramid • Mijanserin • Mirtazapin • Olanzapin • Ondansetron • Palonosetron • Ramosetron • Rikasetron • Tropisetron • Zatosetron
Alizaprid • Bromoprid • Hlorpromazin • Kleboprid • Domperidon • Haloperidol • Itoprid • Metoklopramid • Metopimazin • Prohlorperazin • Tietilperazin