ADORA1 |
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Ідентифікатори |
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Символи | ADORA1, RDC7, adenosine A1 receptor |
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Зовнішні ІД | OMIM: 102775 MGI: 99401 HomoloGene: 20165 GeneCards: ADORA1 |
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Реагує на сполуку |
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Аденозин, BAY 60-6583, Regadenoson, CCPA, CGS-21680, cyclopentyladenosine, 8-cyclopentyltheophylline, кофеїн, CGS 15943, 8-cyclopentyl-1,3-dipropylxanthine, isobutylmethylxanthine, istradefylline, preladenant, rolofylline, sch-442416, sch-58261, Теофілін, ZM-241385, Аденозин, FK-453, gs-9667, tecadenoson, tonapofylline[1] |
Онтологія гена |
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Молекулярна функція | • G-protein beta/gamma-subunit complex binding • G protein-coupled adenosine receptor activity • G protein-coupled receptor activity • signal transducer activity • purine nucleoside binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • phospholipase C activity • heterotrimeric G-protein binding • G protein-coupled receptor binding • heat shock protein binding • neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration |
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Клітинна компонента | • integral component of membrane • cell body • postsynaptic membrane • мембрана • GO:0097483, GO:0097481 постсинаптичне ущільнення • dendritic spine • синапс • integral component of plasma membrane • presynaptic active zone • terminal bouton • neuronal cell body • дендрит (нейробіологія) • basolateral plasma membrane • ендоплазматичний ретикулум • axolemma • asymmetric synapse • presynaptic membrane • система ендомембран • клітинна мембрана • integral component of postsynaptic membrane • integral component of presynaptic membrane • calyx of Held |
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Біологічний процес | • negative regulation of circadian sleep/wake cycle, non-REM sleep • positive regulation of nucleoside transport • positive regulation of epidermal growth factor-activated receptor activity • G protein-coupled adenosine receptor signaling pathway • negative regulation of neurotrophin production • negative regulation of glutamate secretion • response to hypoxia • negative regulation of acute inflammatory response • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of sensory perception of pain • когнітивність • positive regulation of protein dephosphorylation • negative regulation of blood pressure • negative regulation of heart contraction • protein targeting to membrane • positive regulation of potassium ion transport • regulation of glomerular filtration • cell-cell signaling • positive regulation of peptide secretion • negative regulation of apoptotic process • нейробіологія розвитку • detection of temperature stimulus involved in sensory perception of pain • regulation of respiratory gaseous exchange by nervous system process • lipid catabolic process • negative regulation of circadian sleep/wake cycle, sleep • positive regulation of blood pressure • negative regulation of synaptic transmission, GABAergic • negative regulation of renal sodium excretion • excitatory postsynaptic potential • Фагоцитоз • relaxation of vascular associated smooth muscle • apoptotic signaling pathway • regulation of cardiac muscle contraction • negative regulation of long-term synaptic depression • temperature homeostasis • inflammatory response • negative regulation of mucus secretion • negative regulation of hormone secretion • negative regulation of lipid catabolic process • negative regulation of inflammatory response • negative regulation of leukocyte migration • negative regulation of synaptic transmission, glutamatergic • GO:0072468 сигнальна трансдукція • negative regulation of cell population proliferation • negative regulation of cardiac muscle contraction • G protein-coupled receptor signaling pathway • positive regulation of systemic arterial blood pressure • negative regulation of systemic arterial blood pressure • positive regulation of lipid catabolic process • fatty acid homeostasis • triglyceride homeostasis • negative regulation of long-term synaptic potentiation • positive regulation of neuron death • regulation of cardiac muscle cell contraction • regulation of presynaptic cytosolic calcium ion concentration |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000674 NM_001048230 NM_001365065 NM_001365066 |
| NM_001008533 NM_001039510 NM_009629 NM_001282945 NM_001291928
| NM_001291930 |
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RefSeq (білок) | | NP_000665 NP_001041695 NP_001351994 NP_001351995 |
| | NP_001008533 NP_001034599 NP_001269874 NP_001278857 NP_001278859 |
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Локус (UCSC) | Хр. 1: 203.09 – 203.17 Mb | Хр. 1: 134.13 – 134.16 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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