ADORA2A |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IUA, 5IU8, 5IUB | | |
Ідентифікатори |
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Символи | ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8 |
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Зовнішні ІД | OMIM: 102776 MGI: 99402 HomoloGene: 20166 GeneCards: ADORA2A |
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Реагує на сполуку |
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Аденозин, BAY 60-6583, Regadenoson, UK-432,097, CCPA, CGS-21680, cyclopentyladenosine, кофеїн, CGS 15943, 8-cyclopentyl-1,3-dipropylxanthine, flavone, galangin, istradefylline, morin, preladenant, rolofylline, sakuranetin, sch-442416, sch-58261, Теофілін, ZM-241385[1] |
Онтологія гена |
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Молекулярна функція | • G protein-coupled adenosine receptor activity • G protein-coupled receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • alpha-actinin binding • type 5 metabotropic glutamate receptor binding • protein heterodimerization activity |
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Клітинна компонента | • integral component of membrane • мембрана • клітинна мембрана • integral component of plasma membrane • Проміжні філаменти • система ендомембран • GO:0097483, GO:0097481 постсинаптичне ущільнення • аксон • дендрит (нейробіологія) • axolemma • asymmetric synapse • presynaptic membrane • neuronal cell body • postsynaptic membrane • presynaptic active zone • integral component of postsynaptic membrane • integral component of presynaptic membrane • glutamatergic synapse • Golgi membrane |
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Біологічний процес | • cAMP biosynthetic process • G protein-coupled adenosine receptor signaling pathway • sensory perception • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell-cell signaling • зсідання крові • кровообіг • cellular defense response • central nervous system development • Фагоцитоз • inflammatory response • GO:0072468 сигнальна трансдукція • GO:0097285 апоптоз • synaptic transmission, dopaminergic • response to amphetamine • GO:0009373 regulation of transcription, DNA-templated • negative regulation of protein kinase activity • protein kinase C-activating G protein-coupled receptor signaling pathway • synaptic transmission, cholinergic • locomotory behavior • negative regulation of cell population proliferation • positive regulation of glutamate secretion • positive regulation of acetylcholine secretion, neurotransmission • regulation of norepinephrine secretion • response to caffeine • positive regulation of synaptic transmission, GABAergic • synaptic transmission, glutamatergic • positive regulation of urine volume • positive regulation of renal sodium excretion • negative regulation of locomotion • вазодилатація • харчова поведінка • negative regulation of vascular permeability • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to alkaloid • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of circadian sleep/wake cycle, sleep • negative regulation of alpha-beta T cell activation • astrocyte activation • neuron projection morphogenesis • positive regulation of protein secretion • negative regulation of inflammatory response • regulation of mitochondrial membrane potential • membrane depolarization • regulation of calcium ion transport • positive regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • Гальмівний постсинаптичний потенціал • prepulse inhibition • positive regulation of apoptotic signaling pathway • G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of long-term synaptic potentiation • regulation of synaptic vesicle exocytosis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000675 NM_001278497 NM_001278498 NM_001278499 NM_001278500 |
| | NM_009630 NM_001331095 NM_001331096 |
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RefSeq (білок) | | NP_000666 NP_001265426 NP_001265427 NP_001265428 NP_001265429 |
| | NP_001318024 NP_001318025 NP_033760 |
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Локус (UCSC) | Хр. 22: 24.42 – 24.44 Mb | Хр. 10: 75.15 – 75.17 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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