DRD2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | | |
Ідентифікатори |
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Символи | DRD2, D2DR, D2R, dopamine receptor D2 |
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Зовнішні ІД | OMIM: 126450 MGI: 94924 HomoloGene: 22561 GeneCards: DRD2 |
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Пов'язані генетичні захворювання |
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великий депресивний розлад[1] |
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Реагує на сполуку |
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remoxipride[2] |
benzquinamide, LP-12, LP-211, LP-44, ропінірол, ротиготин, vilazodone, 7-hydroxy-2-(di-N-propylamino)tetralin, бромокриптин, дофамін, pergolide, праміпексол, quinelorane, quinpirole, sumanirole, апоморфін, арипіпразол, brexpiprazole, каберголін, lisuride, пірибедил, roxindole, terguride, амісульприд, blonanserin, (+)-butaclamol, хлорпромазин, клозапін, домперидон, eticlopride, флюпентиксол, Флуфеназин, галоперидол, L-741,626, Локсапін, mesoridazine, nafadotride, оланзапін, perospirone, перфеназин, пімозид, pipotiazine, прохлорперазин, промазин, кветіапін, raclopride, рисперидон, сертиндол, сульпірид, levosulpiride, Трифлуоперазин, зипразидон, zotepine[3] |
Онтологія гена |
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Молекулярна функція | • protein homodimerization activity • potassium channel regulator activity • dopamine neurotransmitter receptor activity, coupled via Gi/Go • identical protein binding • dopamine neurotransmitter receptor activity • G protein-coupled receptor activity • GO:0001948, GO:0016582 protein binding • signal transducer activity • adrenergic receptor activity • dopamine binding • signaling receptor binding • ionotropic glutamate receptor binding • protein heterodimerization activity |
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Клітинна компонента | • GO:0016023 cytoplasmic vesicle • sperm flagellum • endocytic vesicle • Акросома • dendritic spine • synaptic vesicle membrane • перикаріон • клітинна мембрана • дендрит (нейробіологія) • ciliary membrane • axon terminus • integral component of membrane • GO:0097483, GO:0097481 постсинаптичне ущільнення • мембрана • lateral plasma membrane • аксон • внутрішньоклітинний • non-motile cilium • integral component of plasma membrane • dopaminergic synapse • glutamatergic synapse • GABA-ergic synapse • integral component of postsynaptic membrane • integral component of presynaptic membrane |
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Біологічний процес | • negative regulation of cell population proliferation • temperature homeostasis • adenylate cyclase-inhibiting dopamine receptor signaling pathway • adenohypophysis development • circadian regulation of gene expression • response to toxic substance • regulation of dopamine secretion • response to cocaine • response to amphetamine • sensory perception of smell • locomotory behavior • positive regulation of urine volume • response to ethanol • аксоноґенеза • response to inactivity • phospholipase C-activating dopamine receptor signaling pathway • modulation of chemical synaptic transmission • марафет • negative regulation of protein kinase B signaling • associative learning • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • regulation of dopamine uptake involved in synaptic transmission • regulation of synaptic transmission, GABAergic • positive regulation of dopamine uptake involved in synaptic transmission • GO:0072468 сигнальна трансдукція • Wnt signaling pathway • adult walking behavior • branching morphogenesis of a nerve • negative regulation of cytosolic calcium ion concentration • negative regulation of innate immune response • regulation of phosphoprotein phosphatase activity • acid secretion • харчова поведінка • positive regulation of G protein-coupled receptor signaling pathway • response to axon injury • striatum development • synaptic transmission, dopaminergic • nervous system process involved in regulation of systemic arterial blood pressure • перистальтика • regulation of long-term neuronal synaptic plasticity • activation of protein kinase activity • positive regulation of growth hormone secretion • regulation of sodium ion transport • forebrain development • response to light stimulus • orbitofrontal cortex development • prepulse inhibition • response to morphine • response to iron ion • positive regulation of ERK1 and ERK2 cascade • довготривала пам'ять • positive regulation of renal sodium excretion • negative regulation of insulin secretion • neuron-neuron synaptic transmission • GO:0007243 intracellular signal transduction • auditory behavior • behavioral response to ethanol • регуляція серцевого ритму • adenylate cyclase-activating adrenergic receptor signaling pathway • positive regulation of cytokinesis • regulation of potassium ion transport • pigmentation • cellular calcium ion homeostasis • dopamine metabolic process • response to nicotine • regulation of MAPK cascade • response to histamine • negative regulation of synaptic transmission, glutamatergic • response to hypoxia • negative regulation of circadian sleep/wake cycle, sleep • negative regulation of protein secretion • synapse assembly • regulation of locomotion involved in locomotory behavior • dopamine receptor signaling pathway • negative regulation of dopamine receptor signaling pathway • переляк • positive regulation of receptor internalization • GO:0034613 protein localization • arachidonic acid secretion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • G protein-coupled receptor internalization • positive regulation of multicellular organism growth • positive regulation of long-term synaptic potentiation • negative regulation of dopamine secretion • adult behavior • cerebral cortex GABAergic interneuron migration • regulation of synapse structural plasticity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • visual learning • negative regulation of cell migration • behavioral response to cocaine • positive regulation of neuroblast proliferation • negative regulation of blood pressure • release of sequestered calcium ion into cytosol • negative regulation of voltage-gated calcium channel activity • G protein-coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • excitatory postsynaptic potential • GO:0033128 negative regulation of protein phosphorylation • автофагія • positive regulation of neurogenesis • negative regulation of cell death • drinking behavior • adrenergic receptor signaling pathway • regulation of neurotransmitter uptake • postsynaptic modulation of chemical synaptic transmission • regulation of synaptic vesicle exocytosis |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | |
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RefSeq (білок) | | NP_000786 NP_057658 NP_000786.1 |
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Локус (UCSC) | Хр. 11: 113.41 – 113.48 Mb | Хр. 9: 49.25 – 49.32 Mb |
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PubMed search | [4] | [5] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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