TLR2 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1FYW, 1FYX, 1O77, 2Z7X, 2Z80 | | |
Ідентифікатори |
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Символи | TLR2, CD282, TIL4, toll like receptor 2 |
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Зовнішні ІД | OMIM: 603028 MGI: 1346060 HomoloGene: 20695 GeneCards: TLR2 |
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Онтологія гена |
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Молекулярна функція | • GO:0008329 pattern recognition receptor activity • lipopolysaccharide binding • Toll-like receptor binding • triacyl lipopeptide binding • GO:0001948, GO:0016582 protein binding • peptidoglycan binding • protein heterodimerization activity • lipopolysaccharide immune receptor activity • transmembrane signaling receptor activity • ліпопептидний зв'язок |
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Клітинна компонента | • цитоплазма • integral component of membrane • phagocytic vesicle membrane • комплекс Ґольджі • мембрана • intrinsic component of plasma membrane • клітинна мембрана • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • membrane raft • GO:0016023 cytoplasmic vesicle • cell projection • cell surface • cell body |
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Біологічний процес | • interleukin-10 production • positive regulation of interferon-beta production • GO:0051637 defense response to Gram-positive bacterium • positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of inflammatory response • cellular response to bacterial lipopeptide • positive regulation of interleukin-12 production • процес імунної системи • detection of diacyl bacterial lipopeptide • cellular response to diacyl bacterial lipopeptide • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • positive regulation of Wnt signaling pathway • GO:1901313 positive regulation of gene expression • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of chemokine production • вроджений імунітет • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • response to molecule of bacterial origin • GO:0072468 сигнальна трансдукція • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 апоптоз • response to lipopolysaccharide • response to progesterone • toll-like receptor signaling pathway • response to insulin • central nervous system myelin formation • nitric oxide metabolic process • response to fatty acid • leukotriene metabolic process • toll-like receptor 2 signaling pathway • positive regulation of oligodendrocyte differentiation • response to bacterial lipoprotein • negative regulation of cell population proliferation • response to toxic substance • response to hypoxia • positive regulation of interleukin-10 production • lipopolysaccharide-mediated signaling pathway • microglial cell activation |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | NM_003264 NM_001318787 NM_001318789 NM_001318790 NM_001318791
| NM_001318793 NM_001318795 NM_001318796 |
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RefSeq (білок) | NP_001305716 NP_001305718 NP_001305719 NP_001305720 NP_001305722
| NP_001305724 NP_001305725 NP_003255 |
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Локус (UCSC) | Хр. 4: 153.68 – 153.71 Mb | Хр. 3: 83.74 – 83.75 Mb |
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PubMed search | [1] | [2] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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