CDK12 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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4CXA, 4NST, 4UN0, 5ACB |
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Identifiers |
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Aliases | CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12 |
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External IDs | OMIM: 615514; MGI: 1098802; HomoloGene: 128632; GeneCards: CDK12; OMA:CDK12 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 17 (human)[1] |
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| Band | 17q12 | Start | 39,461,486 bp[1] |
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End | 39,564,907 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 D|11 61.75 cM | Start | 98,093,885 bp[2] |
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End | 98,169,330 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - buccal mucosa cell
- sural nerve
- secondary oocyte
- epithelium of colon
- ganglionic eminence
- gastric mucosa
- ventricular zone
- Achilles tendon
- skin of leg
- tonsil
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| Top expressed in | - zygote
- secondary oocyte
- ascending aorta
- tail of embryo
- Rostral migratory stream
- aortic valve
- genital tubercle
- granulocyte
- spermatocyte
- primary oocyte
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- protein kinase activity
- nucleotide binding
- kinase activity
- protein serine/threonine kinase activity
- protein binding
- RNA polymerase II CTD heptapeptide repeat kinase activity
- ATP binding
- cyclin binding
- cyclin-dependent protein serine/threonine kinase activity
- transcription factor binding
- protein kinase binding
| Cellular component | - nuclear speck
- nuclear cyclin-dependent protein kinase holoenzyme complex
- cyclin K-CDK12 complex
- nucleus
- nucleoplasm
- fibrillar center
- chromosome
- cyclin/CDK positive transcription elongation factor complex
- cyclin-dependent protein kinase holoenzyme complex
| Biological process | - phosphorylation of RNA polymerase II C-terminal domain
- phosphorylation
- mRNA processing
- regulation of cell cycle
- protein phosphorylation
- regulation of RNA splicing
- RNA splicing
- protein autophosphorylation
- regulation of MAP kinase activity
- transcription elongation from RNA polymerase II promoter
- positive regulation of transcription by RNA polymerase II
- negative regulation of stem cell differentiation
- positive regulation of transcription elongation from RNA polymerase II promoter
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001109626 NM_001109628 NM_026952 |
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RefSeq (protein) | | |
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NP_001103096 NP_001103098 NP_081228 |
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Location (UCSC) | Chr 17: 39.46 – 39.56 Mb | Chr 11: 98.09 – 98.17 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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