EIF2AK4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1UKX, 4OTN |
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Identifiers |
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Aliases | EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4 |
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External IDs | OMIM: 609280; MGI: 1353427; HomoloGene: 40891; GeneCards: EIF2AK4; OMA:EIF2AK4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 15 (human)[1] |
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| Band | 15q15.1 | Start | 39,934,115 bp[1] |
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End | 40,035,591 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 2 (mouse)[2] |
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| Band | 2|2 E5 | Start | 118,219,099 bp[2] |
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End | 118,305,715 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - anterior pituitary
- bone marrow cells
- stromal cell of endometrium
- synovial membrane
- tibia
- Achilles tendon
- Brodmann area 9
- nucleus accumbens
- left uterine tube
- caudate nucleus
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| Top expressed in | - medullary collecting duct
- secondary oocyte
- primary oocyte
- zygote
- saccule
- otic placode
- Paneth cell
- external carotid artery
- epithelium of lens
- internal carotid artery
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- tRNA binding
- kinase activity
- protein serine/threonine kinase activity
- RNA binding
- ATP binding
- eukaryotic translation initiation factor 2alpha kinase activity
| Cellular component | - cytoplasm
- polysome
- cytosolic ribosome
| Biological process | - positive regulation of translational initiation in response to starvation
- adaptive immune response
- negative regulation of neuron differentiation
- positive regulation of long-term synaptic potentiation
- positive regulation of adaptive immune response
- negative regulation of translational initiation in response to stress
- negative regulation of translational initiation
- phosphorylation
- immune system process
- cellular response to UV
- cellular response to amino acid starvation
- negative regulation of CREB transcription factor activity
- regulation of feeding behavior
- learning
- nervous system development
- viral translation
- neuron projection extension
- protein phosphorylation
- cellular response to cold
- long-term memory
- defense response to virus
- cellular response to leucine starvation
- eiF2alpha phosphorylation in response to endoplasmic reticulum stress
- induction by virus of host autophagy
- protein autophosphorylation
- cell cycle
- negative regulation by host of viral genome replication
- viral process
- regulation of translation
- regulation of translational initiation
- positive regulation of defense response to virus by host
- T cell activation involved in immune response
- DNA damage checkpoint signaling
- regulation of translational initiation by eIF2 alpha phosphorylation
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_001177806 NM_013719 NM_001355383 |
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RefSeq (protein) | | |
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NP_001171277 NP_038747 NP_001342312 |
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Location (UCSC) | Chr 15: 39.93 – 40.04 Mb | Chr 2: 118.22 – 118.31 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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