PRKAA2 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2H6D, 2LTU, 2YZA, 3AQV, 4CFE, 4CFF, 4ZHX, 5EZV |
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Identifiers |
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Aliases | PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2 |
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External IDs | OMIM: 600497; MGI: 1336173; HomoloGene: 4551; GeneCards: PRKAA2; OMA:PRKAA2 - orthologs |
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EC number | 2.7.11.27 |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p32.2 | Start | 56,645,314 bp[1] |
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End | 56,715,335 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 C6 | Start | 104,887,071 bp[2] |
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End | 104,967,087 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Skeletal muscle tissue of rectus abdominis
- biceps brachii
- Skeletal muscle tissue of biceps brachii
- right ventricle
- body of tongue
- renal medulla
- saphenous vein
- muscle of thigh
- vena cava
- Brodmann area 23
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| Top expressed in | - triceps brachii muscle
- medial head of gastrocnemius muscle
- vastus lateralis muscle
- sternocleidomastoid muscle
- tibialis anterior muscle
- knee joint
- digastric muscle
- temporal muscle
- soleus muscle
- extraocular muscle
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- nucleotide binding
- protein kinase activity
- [acetyl-CoA carboxylase kinase activity]
- AMP-activated protein kinase activity
- histone serine kinase activity
- chromatin binding
- metal ion binding
- kinase activity
- protein serine/threonine kinase activity
- protein binding
- [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity]
- protein serine/threonine/tyrosine kinase activity
- ATP binding
| Cellular component | - cytoplasm
- cytosol
- nucleoplasm
- nucleotide-activated protein kinase complex
- nucleus
- Golgi apparatus
- nuclear speck
- cytoplasmic stress granule
- axon
- dendrite
- neuronal cell body
| Biological process | - carnitine shuttle
- steroid metabolic process
- intracellular signal transduction
- cellular response to glucose starvation
- sterol biosynthetic process
- lipid biosynthetic process
- regulation of transcription, DNA-templated
- glucose homeostasis
- positive regulation of autophagy
- phosphorylation
- rhythmic process
- lipid metabolism
- response to stress
- negative regulation of apoptotic process
- cholesterol metabolic process
- Wnt signaling pathway
- regulation of fatty acid biosynthetic process
- fatty acid metabolic process
- transcription, DNA-templated
- cellular response to prostaglandin E stimulus
- autophagy
- protein phosphorylation
- negative regulation of TOR signaling
- positive regulation of macroautophagy
- fatty acid biosynthetic process
- fatty acid homeostasis
- regulation of circadian rhythm
- cellular response to nutrient levels
- regulation of gene expression
- cholesterol biosynthetic process
- response to muscle activity
- positive regulation of glycolytic process
- macroautophagy
- signal transduction
- steroid biosynthetic process
- regulation of signal transduction by p53 class mediator
- regulation of macroautophagy
- chromatin organization
- negative regulation of gene expression
- cellular response to oxidative stress
- regulation of stress granule assembly
- regulation of microtubule cytoskeleton organization
- cellular response to calcium ion
- cellular response to glucose stimulus
- energy homeostasis
- positive regulation of protein localization
- negative regulation of tubulin deacetylation
- positive regulation of peptidyl-lysine acetylation
| Sources:Amigo / QuickGO |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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