KIF25 |
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Identifiers |
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Aliases | KIF25, KNSL3, kinesin family member 25 |
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External IDs | OMIM: 603815; HomoloGene: 49939; GeneCards: KIF25; OMA:KIF25 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 6 (human)[1] |
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| Band | 6q27 | Start | 167,996,241 bp[1] |
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End | 168,045,091 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - gonad
- buccal mucosa cell
- testicle
- right hemisphere of cerebellum
- apex of heart
- C1 segment
- abdominal fat
- right frontal lobe
- putamen
- dorsolateral prefrontal cortex
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| | More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - microtubule binding
- microtubule motor activity
- nucleotide binding
- ATPase activity
- ATP binding
- minus-end-directed microtubule motor activity
| Cellular component | - cytoplasm
- microtubule
- cytoskeleton
- kinesin complex
- centrosome
- microtubule organizing center
| Biological process | - microtubule-based movement
- negative regulation of autophagy
- organelle organization
- mitotic sister chromatid segregation
- negative regulation of mitotic centrosome separation
- protein homotetramerization
- establishment of spindle orientation
- nucleus localization
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 6: 168 – 168.05 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Motor protein found in humans
Kinesin family member 25 (KIF25), also known as kinesin-14, is a human protein encoded by the KIF25 gene. It is part of the kinesin family of motor proteins.
Function
KIF25 is a minus-end directed microtubule motor protein, and its activity delays the separation of chromosomes during mitosis.[3]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000125337 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Decarreau J, Wagenbach M, Lynch E, Halpern AR, Vaughan JC, Kollman J, Wordeman L (April 2017). "The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation". Nature Cell Biology. 19 (4): 384–390. doi:10.1038/ncb3486. PMC 5376238. PMID 28263957.