IRAK3 |
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Identifiers |
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Aliases | IRAK3, ASRT5, IRAKM, interleukin 1 receptor associated kinase 3 |
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External IDs | OMIM: 604459; MGI: 1921164; HomoloGene: 36215; GeneCards: IRAK3; OMA:IRAK3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q14.3 | Start | 66,189,195 bp[1] |
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End | 66,254,622 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 10 (mouse)[2] |
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| Band | 10|10 D2 | Start | 119,977,553 bp[2] |
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End | 120,038,035 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - monocyte
- bone marrow
- parietal pleura
- blood
- right lung
- bone marrow cells
- palpebral conjunctiva
- spleen
- lower lobe of lung
- trabecular bone
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| Top expressed in | - granulocyte
- gastrula
- spermatocyte
- seminiferous tubule
- spermatid
- bone marrow
- ankle
- sciatic nerve
- lip
- blood
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - nucleotide binding
- protein kinase activity
- transferase activity
- magnesium ion binding
- protein serine/threonine kinase activity
- kinase activity
- protein homodimerization activity
- protein heterodimerization activity
- ATP binding
- protein binding
| Cellular component | - cytoplasm
- nucleus
- plasma membrane
| Biological process | - response to lipopolysaccharide
- negative regulation of innate immune response
- signal transduction
- negative regulation of macrophage cytokine production
- protein autophosphorylation
- negative regulation of protein-containing complex disassembly
- response to interleukin-1
- response to exogenous dsRNA
- protein phosphorylation
- negative regulation of toll-like receptor signaling pathway
- cytokine-mediated signaling pathway
- response to virus
- response to peptidoglycan
- negative regulation of cytokine-mediated signaling pathway
- regulation of protein-containing complex disassembly
- positive regulation of macrophage tolerance induction
- negative regulation of NF-kappaB transcription factor activity
- phosphorylation
- negative regulation of protein catabolic process
- negative regulation of interleukin-6 production
- interleukin-1-mediated signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of MAP kinase activity
- negative regulation of tumor necrosis factor production
- negative regulation of interleukin-12 production
- MyD88-dependent toll-like receptor signaling pathway
- intracellular signal transduction
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 12: 66.19 – 66.25 Mb | Chr 10: 119.98 – 120.04 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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