Толл-подобный рецептор 4 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/TLR4.png/250px-TLR4.png) |
Доступные структуры |
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PDB | Поиск ортологов: PDBe RCSB |
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Список идентификаторов PDB |
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4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA |
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Идентификаторы |
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Псевдонимы | TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4 |
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Внешние ID | OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4 |
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Расположение гена (Мышь) |
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![4-я хромосома мыши](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | Хр. | 4-я хромосома мыши[2] |
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| Локус | 4 C1|4 34.66 cM | Начало | 66,745,821 bp[2] |
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Конец | 66,848,521 bp[2] |
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Паттерн экспрессии РНК |
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Bgee | Человек | Мышь (ортолог) |
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| Наибольшая экспрессия в | - lumbar spinal ganglion
- decidua
- epithelium of stomach
- stroma of bone marrow
- endothelial cell of lymphatic vessel
- mucous cell of stomach
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PBB_GE_TLR4_221060_s_at_fs.png/250px-PBB_GE_TLR4_221060_s_at_fs.png) | Дополнительные справочные данные |
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Генная онтология |
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Молекулярная функция | - lipopolysaccharide immune receptor activity
- lipopolysaccharide binding
- связывание с белками плазмы
- transmembrane signaling receptor activity
| Компонент клетки | - цитоплазма
- мембрана
- perinuclear region of cytoplasm
- поверхность клетки
- часть мембраны
- клеточная мембрана
- endosome membrane
- intrinsic component of plasma membrane
- часть клеточной мембраны
- lipopolysaccharide receptor complex
- наружная сторона клеточной мембраны
| Биологический процесс | - positive regulation of MHC class II biosynthetic process
- positive regulation of JNK cascade
- TRIF-dependent toll-like receptor signaling pathway
- cellular response to mechanical stimulus
- positive regulation of interleukin-8 production
- positive regulation of ERK1 and ERK2 cascade
- T-helper 1 type immune response
- positive regulation of platelet activation
- positive regulation of interleukin-1 production
- positive regulation of stress-activated MAPK cascade
- positive regulation of NLRP3 inflammasome complex assembly
- positive regulation of interleukin-12 production
- positive regulation of interferon-alpha production
- I-kappaB phosphorylation
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of B cell proliferation
- defense response to bacterium
- positive regulation of interleukin-6 production
- activation of innate immune response
- positive regulation of tumor necrosis factor production
- negative regulation of tumor necrosis factor production
- врождённый иммунитет
- negative regulation of interleukin-17 production
- I-kappaB kinase/NF-kappaB signaling
- positive regulation of interferon-beta production
- positive regulation of inflammatory response
- toll-like receptor 4 signaling pathway
- positive regulation of macrophage cytokine production
- positive regulation of interleukin-10 production
- immune system process
- astrocyte development
- intestinal epithelial structure maintenance
- positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
- response to lipopolysaccharide
- cellular response to lipoteichoic acid
- positive regulation of NF-kappaB transcription factor activity
- иммунный ответ
- negative regulation of interleukin-23 production
- regulation of inflammatory response
- positive regulation of chemokine production
- lipopolysaccharide-mediated signaling pathway
- detection of fungus
- positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of interferon-gamma production
- response to bacterium
- negative regulation of osteoclast differentiation
- B cell proliferation involved in immune response
- positive regulation of nitric oxide biosynthetic process
- negative regulation of interleukin-6 production
- positive regulation of interferon-gamma production
- nitric oxide production involved in inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- regulation of dendritic cell cytokine production
- positive regulation of gene expression
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- macrophage activation
- detection of lipopolysaccharide
- cellular response to lipopolysaccharide
- positive regulation of lymphocyte proliferation
- положительная регуляция транскрипции РНК полимеразой II промотор
- MyD88-independent toll-like receptor signaling pathway
- передача сигнала
- воспалительная реакция
- defense response to Gram-negative bacterium
- toll-like receptor signaling pathway
- Некроптоз
- apoptotic signaling pathway
- negative regulation of MyD88-independent toll-like receptor signaling pathway
| Источники: Amigo, QuickGO |
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Ортологи |
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Вид | Человек | Мышь |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | |
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NM_138557 NM_003266 NM_138554 NM_138556 |
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RefSeq (белок) | |
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NP_003257 NP_612564 NP_612567 |
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Локус (UCSC) | Chr 9: 117.7 – 117.72 Mb | Chr 4: 66.75 – 66.85 Mb |
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Поиск по PubMed | Искать[3] | Искать[4] |
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Информация в Викиданных |
Смотреть (человек) | Смотреть (мышь) |
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