OR10A4

Protein-coding gene in the species Homo sapiens
OR10A4
Identifiers
AliasesOR10A4, JCG5, OR10A4P, olfactory receptor family 10 subfamily A member 4
External IDsMGI: 109148; HomoloGene: 23241; GeneCards: OR10A4; OMA:OR10A4 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR10A4
Genomic location for OR10A4
Band11p15.4Start6,876,625 bp[1]
End6,877,619 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR10A4
Genomic location for OR10A4
Band7|7 E3Start106,692,427 bp[2]
End106,699,015 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • bone marrow cells

  • corpus callosum

  • placenta
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium

  • gastrula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • axon guidance
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

283297

18314

Ensembl

ENSG00000170782

ENSMUSG00000073897

UniProt

Q9H209

Q7TRM9

RefSeq (mRNA)

NM_207186

NM_020598

RefSeq (protein)

NP_997069

NP_065623

Location (UCSC)Chr 11: 6.88 – 6.88 MbChr 7: 106.69 – 106.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 10A4 is a protein that in humans is encoded by the OR10A4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170782 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073897 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR10A4 olfactory receptor, family 10, subfamily A, member 4".

Further reading

  • Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi:10.1073/pnas.131215398. PMC 34679. PMID 11416212.
  • Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi:10.1093/chemse/26.9.1157. PMID 11705801.
  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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