OR6C3

Protein-coding gene in the species Homo sapiens
OR6C3
Identifiers
AliasesOR6C3, OST709, olfactory receptor family 6 subfamily C member 3
External IDsMGI: 3030637; HomoloGene: 105153; GeneCards: OR6C3; OMA:OR6C3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for OR6C3
Genomic location for OR6C3
Band12q13.2Start55,330,043 bp[1]
End55,332,687 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for OR6C3
Genomic location for OR6C3
Band10|10 D3Start129,526,490 bp[2]
End129,530,155 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • fundus
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • signal transducer activity
  • G protein-coupled receptor activity
  • olfactory receptor activity
Cellular component
  • plasma membrane
  • membrane
  • integral component of membrane
Biological process
  • signal transduction
  • response to stimulus
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

254786

258547

Ensembl

ENSG00000205329

ENSMUSG00000046041

UniProt

Q9NZP0

Q8VFI3

RefSeq (mRNA)

NM_054104
NM_001388498

NM_146554

RefSeq (protein)

NP_473445

NP_666765

Location (UCSC)Chr 12: 55.33 – 55.33 MbChr 10: 129.53 – 129.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 6C3 is a protein that in humans is encoded by the OR6C3 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205329 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046041 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR6C3 olfactory receptor, family 6, subfamily C, member 3".

Further reading

  • Rouquier S, Blancher A, Giorgi D (2000). "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2870–4. Bibcode:2000PNAS...97.2870R. doi:10.1073/pnas.040580197. PMC 16022. PMID 10706615.
  • Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi:10.1038/nature04569. PMID 16541075.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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