OR52L1

Protein-coding gene in the species Homo sapiens
OR52L1
Identifiers
AliasesOR52L1, OR11-50, olfactory receptor family 52 subfamily L member 1, olfactory receptor family 52 subfamily L member 1 (gene/pseudogene)
External IDsMGI: 3030519; HomoloGene: 66455; GeneCards: OR52L1; OMA:OR52L1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR52L1
Genomic location for OR52L1
Band11p15.4Start5,985,892 bp[1]
End5,986,985 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR52L1
Genomic location for OR52L1
Band7|7 E3Start104,827,623 bp[2]
End104,835,219 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • fundus

  • body of stomach

  • left ventricle
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

338751

258160

Ensembl

ENSG00000183313

ENSMUSG00000047794

UniProt

Q8NGH7

n/a

RefSeq (mRNA)

NM_001005173

NM_001011857

RefSeq (protein)

NP_001005173

n/a

Location (UCSC)Chr 11: 5.99 – 5.99 MbChr 7: 104.83 – 104.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 52L1 is a protein that in humans is encoded by the OR52L1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183313 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047794 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR52L1 olfactory receptor, family 52, subfamily L, member 1".

Further reading

  • Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural selection on the olfactory receptor gene family in humans and chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC 1180675. PMID 12908129.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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