OR9A2

Protein-coding gene in the species Homo sapiens
OR9A2
Identifiers
AliasesOR9A2, olfactory receptor family 9 subfamily A member 2
External IDsMGI: 3030293; HomoloGene: 83448; GeneCards: OR9A2; OMA:OR9A2 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for OR9A2
Genomic location for OR9A2
Band7q34Start143,026,200 bp[1]
End143,027,132 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for OR9A2
Genomic location for OR9A2
Band6|6 B2.1Start41,745,704 bp[2]
End41,752,111 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • corpus callosum

  • C1 segment

  • substantia nigra

  • prefrontal cortex

  • hippocampus proper

  • placenta

  • temporal lobe

  • amygdala

  • caudate nucleus
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

135924

258569

Ensembl

ENSG00000273914
ENSG00000179468

ENSMUSG00000045479

UniProt

Q8NGT5

Q924H8

RefSeq (mRNA)

NM_001001658

NM_146576

RefSeq (protein)

NP_001001658

NP_666787

Location (UCSC)Chr 7: 143.03 – 143.03 MbChr 6: 41.75 – 41.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 9A2 is a protein that in humans is encoded by the OR9A2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000179468 GRCh38: Ensembl release 89: ENSG00000273914, ENSG00000179468 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045479 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR9A2 olfactory receptor, family 9, subfamily A, member 2".

Further reading

  • Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural selection on the olfactory receptor gene family in humans and chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC 1180675. PMID 12908129.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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