OR10A6

Protein-coding gene in the species Homo sapiens
OR10A6
Identifiers
AliasesOR10A6, OR11-96, olfactory receptor family 10 subfamily A member 6 (gene/pseudogene)
External IDsMGI: 3030353; HomoloGene: 17186; GeneCards: OR10A6; OMA:OR10A6 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR10A6
Genomic location for OR10A6
Band11p15.4Start7,924,592 bp[1]
End7,931,268 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR10A6
Genomic location for OR10A6
Band7|7 E3Start108,492,668 bp[2]
End108,493,627 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of leg

  • skin of abdomen

  • ascending aorta

  • prostate

  • tibial nerve
Top expressed in
  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • olfactory receptor activity
Cellular component
  • membrane
  • plasma membrane
  • integral component of membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390093

277935

Ensembl

ENSG00000279000
ENSG00000280899
ENSG00000276451

ENSMUSG00000066239

UniProt

Q8NH74

n/a

RefSeq (mRNA)

NM_001004461
NM_001389574

NM_207160

RefSeq (protein)

NP_001004461

n/a

Location (UCSC)Chr 11: 7.92 – 7.93 MbChr 7: 108.49 – 108.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 10A6 is a protein that in humans is encoded by the OR10A6 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G-protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000280899, ENSG00000276451 GRCh38: Ensembl release 89: ENSG00000279000, ENSG00000280899, ENSG00000276451 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066239 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR10A6 olfactory receptor, family 10, subfamily A, member 6".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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