OR11A1

Protein-coding gene in the species Homo sapiens
OR11A1
Identifiers
AliasesOR11A1, 6M1-18, OR11A2, dJ994E9.6, hs6M1-18, olfactory receptor family 11 subfamily A member 1
External IDsMGI: 2177479; HomoloGene: 27189; GeneCards: OR11A1; OMA:OR11A1 - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for OR11A1
Genomic location for OR11A1
Band6p22.1Start29,425,504 bp[1]
End29,457,071 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for OR11A1
Genomic location for OR11A1
Band17|17 B1Start37,531,037 bp[2]
End37,537,564 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • right testis

  • left testis
Top expressed in
  • blastocyst

  • respiratory epithelium

  • peripheral nervous system

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • olfactory receptor activity
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • signal transduction
  • response to stimulus
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26531

258507

Ensembl
ENSG00000237258
ENSG00000230780
ENSG00000232289
ENSG00000234347
ENSG00000223898

ENSG00000206517
ENSG00000206472
ENSG00000204694

ENSMUSG00000064121

UniProt

Q9GZK7

Q8VFE3

RefSeq (mRNA)

NM_013937
NM_001394828
NM_001394829

NM_146514

RefSeq (protein)

NP_039225

NP_666725

Location (UCSC)Chr 6: 29.43 – 29.46 MbChr 17: 37.53 – 37.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 11A1 is a protein that in humans is encoded by the OR11A1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c ENSG00000230780, ENSG00000232289, ENSG00000234347, ENSG00000223898, ENSG00000206517, ENSG00000206472, ENSG00000204694 GRCh38: Ensembl release 89: ENSG00000237258, ENSG00000230780, ENSG00000232289, ENSG00000234347, ENSG00000223898, ENSG00000206517, ENSG00000206472, ENSG00000204694 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064121 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR11A1 olfactory receptor, family 11, subfamily A, member 1".

Further reading

  • Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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